Clinical Practice Guideline

Lipid Management Guideline

October 13, 2020

Full Guideline: Lipid Management in Patients with Endocrine Disorders
JCEM | December 2020 (Online October 2020)

Connie Newman (Chair), Michael J. Blaha, Jeffrey B. Boord, Bertrand Cariou, Alan Chait, Henry Fein, Henry Ginsberg, Ira Goldberg (Co-Chair), M. Hassan Murad, Savitha Subramanian, and Lisa R. Tannock

The 2020 guideline on lipid management in patients with endocrine disorders:

  • Emphasizes assessing lipid profiles in patients with endocrine diseases to reduce the risk of ASCVD.
  • Focuses on the consideration of statin therapy and lipid-lowering effects (if any) in patients with certain endocrine disorders.


Resources

    Essential Points

    • Obtain a lipid panel in adults with endocrine disorders.
    • Treat adults with type 2 diabetes and other cardiovascular risk factors with a statin in addition to lifestyle modifications.
    • Consider statin therapy, irrespective of the cardiovascular risk score, in adults with type 1 diabetes who are age 40 years and older.
    • Rule out hypothyroidism before treatment with lipid-lowering medications. In patients with hypothyroidism, re-evaluate the lipid profile when the patient has thyroid hormone levels in the normal range.
    • Consider statin therapy in addition to lifestyle modifications in adults with Cushing syndrome.
    • Use statins rather than hormone therapy to treat high cholesterol in post-menopausal women.
    • Evaluate and treat lipids and other cardiovascular risk factors in women who enter menopause early (before the age of 40-45 years).

    List of Recommendations

    + 1 SCREENING AND CARDIOVASCULAR DISEASE RISK ASSESSMENT

+ 2 HYPERTRIGLYCERIDEMIA

+ 3 TYPE 2 DIABETES MELLITUS

+ 4 TYPE 1 DIABETES MELLITUS

+ 5 TYPE 1 DIABETES MELLITUS

+ 6 THYROID DISEASE

+ 7 EXCESS GLUCOCORTICOIDS

+ 8 DISORDERS OF GROWTH HORMONE SECRETION

+ 9 POLYCYSTIC OVARY SYNDROME

+ 10 MENOPAUSE AND HORMONAL REPLACEMENT

+ 11 HYPOGONDADISM AND TESTOSTERONE REPLACEMENT AND ABUSE

+ 12 GENDER-AFFIRMING HORMONE THERAPY

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