Clinical Practice Guideline

Treatment of Cushing's Syndrome Guideline Resources

August 19, 2015

Full Guideline: Treatment of Cushing's Syndrome
JCEM | August 2015

Lynnette K. Nieman (chair), Beverly M. K. Biller, James W. Findling, M. Hassan Murad, John Newell-Price, Martin O. Savage, and Antoine Tabarin

The 2015 guideline addresses:

  • Picking the optimal treatment to address the underlying cause (e.g., tumor removal)
  • Adjuctive management and treatment of cortisol-dependent comorbidities
  • Approaching second-line therapeutic options


Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline | ENDO 2015



Essential Points

The Endocrine Society recommends that the first-line treatment for endogenous Cushing’s syndrome be the removal of the tumor unless surgery is not possible or unlikely to address the excess cortisol. Surgical removal of the tumor is optimal because it leaves intact the hypothalamic-pituitary-adrenal axis, which is integral to the body’s central stress response.

Summary of Recommendations

+ 1.0 Treatment goals for Cushing’s syndrome

+ 2.0 Optimal adjunctive management

+ 3.0 First-line treatment options

+ 4.0 Remission and recurrence after surgical tumor resection

+ 5.0 Glucocorticoid replacement and discontinuation, and resolution of other hormonal deficiencies

+ 6.0 Second-line therapeutic options

+ 7.0 Approach for long-term follow-up

+ 8.0 Special populations/considerations

On the Go

CPG Mobile App

App screen
Access guideline recommendations, patient information, and clinical education modules for a range of endocrine topics plus dozens of interactive decision algorithms and other point-of-care tools.

Download our CPG Mobile App

Access guideline recommendations, patient information, and clinical education modules for a range of endocrine topics plus dozens of interactive decision algorithms and other point-of-care tools.

On the Go

GUIDELINES Pocket Guides

Pocket Guides
Practical quick-reference tools to help you make accurate clinical decisions at the point of care.

Practical quick-reference tools to help you make accurate clinical decisions at the point of care.

ENDO 2020

Maximize Your Savings

Register Today
Bringing together leading experts, researchers, and the most respected clinicians in the field, ENDO represents a convergence of science and practice that highlights and facilitates breakthrough discoveries in the field of endocrinology.

Early Registration Deadline: December 12, 2019

Bringing together leading experts, researchers, and the most respected clinicians in the field, ENDO represents a convergence of science and practice that highlights and facilitates breakthrough discoveries in the field of endocrinology.

Back to top
Short on time?

We'll come to you...

Get updates on the latest breakthroughs, clinical practice guidelines, and career development opportunities, straight to your inbox

Then take the next step: Set up your free website account and get exclusive access to even more great tools & content!