Clinical Practice Guideline

Treatment of Cushing's Syndrome Guideline Resources

August 19, 2015

Full Guideline: Treatment of Cushing's Syndrome
JCEM | August 2015

Lynnette K. Nieman (chair), Beverly M. K. Biller, James W. Findling, M. Hassan Murad, John Newell-Price, Martin O. Savage, and Antoine Tabarin

The 2015 guideline addresses:

  • Picking the optimal treatment to address the underlying cause (e.g., tumor removal)
  • Adjuctive management and treatment of cortisol-dependent comorbidities
  • Approaching second-line therapeutic options


Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline | ENDO 2015



Essential Points

The Endocrine Society recommends that the first-line treatment for endogenous Cushing’s syndrome be the removal of the tumor unless surgery is not possible or unlikely to address the excess cortisol. Surgical removal of the tumor is optimal because it leaves intact the hypothalamic-pituitary-adrenal axis, which is integral to the body’s central stress response.

Summary of Recommendations

+ 1.0 Treatment goals for Cushing’s syndrome

+ 2.0 Optimal adjunctive management

+ 3.0 First-line treatment options

+ 4.0 Remission and recurrence after surgical tumor resection

+ 5.0 Glucocorticoid replacement and discontinuation, and resolution of other hormonal deficiencies

+ 6.0 Second-line therapeutic options

+ 7.0 Approach for long-term follow-up

+ 8.0 Special populations/considerations

In Search Of

Endocrine Society Guideline Methodologists

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We are seeking two members to undertake training to become GRADE-certified Endocrine Society Guideline Methodologists (ESGM) for the development of Endocrine Society Clinical Practice Guidelines. ESGMs will materially participate in the guideline development process and thus will be guideline authors, and will also gain valuable career development experience in the process.

We are seeking two members to undertake training to become GRADE-certified Endocrine Society Guideline Methodologists (ESGM) for the development of Endocrine Society Clinical Practice Guidelines. ESGMs will materially participate in the guideline development process and thus will be guideline authors, and will also gain valuable career development experience in the process.

Journals

The Best of Endocrine Society Journals 2020

Explore a collection of top articles published in the Endocrine Society journals in 2020, selected on the basis of citations, downloads, and Altmetric score.

Explore a collection of top articles published in the Endocrine Society journals in 2020, selected on the basis of citations, downloads, and Altmetric score.

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