Diagnosis and Treatment of Hyperprolactinemia

Full Guideline: Diagnosis and Treatment of Hyperprolactinemia: An Endocrine Society Clinical Practice Guideline
JCEM February 2011

Shlomo Melmed, Felipe F. Casanueva, Andrew R. Hoffman, David L. Kleinberg, Victor M. Montori, Janet A. Schlechte, John A. H. Wass


The aim was to formulate practice guidelines for the diagnosis and treatment of hyperprolactinemia.


Testing for hyperprolactinemia is straightforward, owing to the ease of ordering a serum prolactin measurement. Accordingly, an evidence-based, cost-effective approach to management of this relatively common endocrine disorder is required.


  • Practice guidelines are presented for diagnosis and treatment of patients with elevated prolactin levels.
  • These include:
    • evidence-based approaches to assessing the cause of hyperprolactinemia,
    • treating drug-induced hyperprolactinemia,
    • and managing prolactinomas in nonpregnant and pregnant subjects.
  • Indications and side effects of therapeutic agents for treating prolactinomas are also presented.

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