Diagnosis and Treatment of Hyperprolactinemia

Full Guideline: Diagnosis and Treatment of Hyperprolactinemia: An Endocrine Society Clinical Practice Guideline
JCEM February 2011

Shlomo Melmed, Felipe F. Casanueva, Andrew R. Hoffman, David L. Kleinberg, Victor M. Montori, Janet A. Schlechte, John A. H. Wass

Objective:

The aim was to formulate practice guidelines for the diagnosis and treatment of hyperprolactinemia.

Introduction:

Testing for hyperprolactinemia is straightforward, owing to the ease of ordering a serum prolactin measurement. Accordingly, an evidence-based, cost-effective approach to management of this relatively common endocrine disorder is required.

Conclusions:

  • Practice guidelines are presented for diagnosis and treatment of patients with elevated prolactin levels.
  • These include:
    • evidence-based approaches to assessing the cause of hyperprolactinemia,
    • treating drug-induced hyperprolactinemia,
    • and managing prolactinomas in nonpregnant and pregnant subjects.
  • Indications and side effects of therapeutic agents for treating prolactinomas are also presented.

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