JCEM Case Reports Journal Article

Immune Checkpoint Inhibitor Endocrinopathies

November 11, 2025

Insights From 3 Unusual Cases

 

Eystein S Husebye
JCEM Case Reports, Volume 3, Issue 11, November 2025, luaf238
https://doi.org/10.1210/jcemcr/luaf238

Abstract

Immune checkpoint inhibitors (ICIs) are monoclonal antibody drugs that have revolutionized cancer therapy and led to dramatically improved survival for aggressive cancers such as malignant melanoma and lung cancer. However, these benefits come with the cost of significant immune-related side effects. Endocrine glands are among those commonly affected, giving rise to potentially fatal complications if not promptly diagnosed and treated.

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