JCEM Case Reports Journal Article

Fatal, Fulminant, Necrotizing Pancreatitis Associated With Recent Tirzepatide Initiation

June 24, 2025
 

Krista Grennan, Courtney Borg, Ashley Meneley, Tyler Janitz, Midiia Shuman, Carla Venegas
JCEM Case Reports, Volume 3, Issue 6, June 2025, luaf087
https://doi.org/10.1210/jcemcr/luaf087

Abstract

As obesity is increasing in prevalence and its associated morbidity and mortality are escalating worldwide, medications like tirzepatide are frequently used for weight loss benefits in patients without diabetes. Tirzepatide has rarely been associated with acute pancreatitis, but there are no reported cases of fulminant, necrotizing pancreatitis resulting in fatality. We present a case of fatal, fulminant, necrotizing pancreatitis in a 64-year-old low-risk female patient with recent tirzepatide initiation. Prior to starting this medication, a case-by-case risk benefit analysis should be performed for each patient. The importance of this should be emphasized by making necrotizing pancreatitis a boxed warning for tirzepatide.

Read the article

 

You may also like...

Publishing Benefits

Author Resource Center

We provide our journal authors with a variety of resources for increasing the discoverability and citation of their published work. Use these tools and tips to broaden the impact of your article.
Publishing Benefits

Author Resource Center

We provide our journal authors with a variety of resources for increasing the discoverability and citation of their published work. Use these tools and tips to broaden the impact of your article.

Thematic Issue

Latest Thematic Issue

immuno-endocrinology
Read our special collections of Endocrine Society journal articles, curated by topic, Altmetric Attention Scores, and Featured Article designations.

Read our special collections of Endocrine Society journal articles, curated by topic, Altmetric Attention Scores, and Featured Article designations.

Back to top

Who We Are

For 100 years, the Endocrine Society has been at the forefront of hormone science and public health. Read about our history and how we continue to serve the endocrine community.