Practical Approach and Management
Alessandro Perri, Simona Fattore, Annamaria Sbordone, Luca Viti, Dario Pitocco, Giovanni Vento
JCEM Case Reports, Volume 2, Issue 7, July 2024, luae109
https://doi.org/10.1210/jcemcr/luae109
Hirata disease, also known as insulin autoimmune syndrome (IAS), is a rare cause of hypoglycemia, due to the presence of insulin autoantibodies (IAA) in the circulating blood. These antibodies are immunoglobulin G (IgG), making placental transfer to the fetus possible. To our knowledge, no reports of IAS have been previously described in the neonatal population. We present a case report of hypoglycemia due to a secondary IAS in a neonate and discuss the management and treatment of the disease.
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