EDC EU Newsletter # 4

January 28, 2021
To help share the latest science-based information on EDCs, we have prepared the following newsletter for policymakers in the EU. We urge policymakers to prioritize specific actions on EDCs, including a coherent identification process linked to control measures to reduce widespread exposures. If you have any questions or requests for content, please reach out to Joe Laakso, PhD, Director of Science Policy at [email protected]
EDC Latest Updates
EDCs and Fertility
29 December, 2020 | This review of peer-reviewed studies concludes that “sub-fertile individuals or couples exhibit higher EDC concentrations, endorsing a positive association between EDC exposure and sub-fertility.

BPA Associated with Breast Cancer Risk in Mexican Women:  
3 January, 2021 | This study examined the urinary levels of free bisphenol A (BPA) in women in Northern Mexico, showing that levels of BPA were higher in breast cancer patients compared with age-matched controls.
Pregnant Women Susceptible to Phthalate Effects
25 December, 2020 | Scientists assessed the levels of several EDCs in pregnant women at different trimesters, finding that women with higher concentrations of phthalate metabolites in their urine during the first trimester were associated with excessive gestational weight gain.

Trace Metals Associated with Poor COVID-19 Outcome
30 December, 2020 | This study assessed the levels of trace metals in patients with covid-19, finding that the levels of these metals were higher in patients with severe cases of disease.
Project FREIA Webinar on EDC Identification
27 October, 2020 | Project FREIA is an EU-funded project that aims to improve identification of chemicals that affect women’s health via disruption of the hormone (endocrine) system. This webinar recording features expert scientists describing the process of EDC identification with the example of butylparaben as a well-known EDC often present in cosmetics.

Our Society welcomed the Commission’s Chemical Strategy for Sustainability and its measures to protect the public from EDCs. We are pleased that the strategy reflects an intention to use hazard identification for EDCs and includes strict measures to prevent EDCs from being used in consumer products. In addition, the strategy calls for stricter data requirements for EDCs across all relevant legislation and to accelerate the development and adoption of better test methods. The practical features and implementation steps will be important, and our Society urges the Commission to clarify these details to permit concrete actions without further delay
Endocrine Society European Union
EDC Task Force
Barbara Demeneix, PhD, DSC, Muséum National D'histoire Naturelle, Paris, France
Jorma Toppari, MD, PhD, University of Turku and Turku University Hospital, Turku, Finland
Ángel Nadal, PhD, IDiBE and CIBERDEM,
Miguel Hernández University of Elche, Alicante, Spain
Katharina M. Main, PhD, University of Copenhagen and Rigshospitalet, Copenhagen, Denmark
Josef Köhrle, Dr. rer. nat., Charité University-Medicine Berlin, Berlin, Germany
GianCarlo Panzica, PhD, University of Torino, Torino, Italy
SCCS Opinions on Chemicals
The Scientific Committee on Consumer Safety (SCCS) recently issued draft opinions on several chemicals, including known EDCs such as resorcinol and propylparaben. Our Society's comments disagree with the SCCS conclusions that such chemicals are safe for use under current use restrictions. We maintain that EDCs, once identified, should be removed from consumer products.
EFSA Review of NMDR
The European Food Safety Agency (EFSA) Scientific Committee has launched an open consultation on its draft opinion on biological plausibility of non-monotonic dose responses (NMDR) and their impact on the risk assessment. NMDR are particularly common in the case of hormones and EDCs; their presence been extensively demonstrated in animal and cellular models and increasingly in humans. Our Society will submit comments on the report in consistent with our Position Statement and the latest science on NMDR.

Second Stakeholder Forum on EDCs
On December 17-18, the European Commission hosted the second annual forum on endocrine disruptors. Josef Köhrle, a member of our Society’s EU EDC Task Force, participated in a closing panel discussion with stakeholders; Dr. Köhrle provided expert comments on the scientific foundation for harms associated with EDCs and highlighted the need to take action on harmful EDCs in consumer products.

EP BECA Committee
On December 11, the European Parliament Beating Cancer Committee heard from experts about the role of environmental exposures in cancer risk. Dr Remy Slama delivered a presentation on chemical exposures, including the risk posed by EDCs that can mimic estrogen.  
Endocrine Society Activities
. Learn  More About EDCs
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals or their mixtures that can interfere with any aspect of hormone action. EDCs such as bisphenols, phthalates, and PFAS are found in food, toys, cosmetics, medicines, and plastics as well as throughout the environment. Scientific evidence has shown that exposure to EDCs has contributed to increases in the incidence of diseases including neurodevelopmental, reproductive, and metabolic disorders, as well as some cancers.
Founded in 1916, the Endocrine Society is the world’s oldest and largest international organization dedicated to research on endocrine science and the clinical treatment of patients with endocrine diseases.  Our members include researchers and clinicians from over 120 countries, including all the member states of the European Union.  Since 2013, the Endocrine Society has made improving regulation of EDCs a top priority and has been the leading voice of endocrine science in global policy efforts. We have hosted several briefings in the European Parliament and numerous meetings with Members of the European Parliament and Commission officials. The Endocrine Society supports effective translation of scientific knowledge on EDCs and their health effects to regulatory policies that protect consumers and improve regulatory testing strategies. 

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