Endocrine-disrupting chemicals (EDCs) are chemicals that mimic, block, or interfere with hormones in the body's endocrine system. EDCs have been associated with a diverse array of health issues. Watch an animated overview to learn more and explore the rest of the Society's education, resources, and advocacy campaigns on EDCs.



European Commission urged to deliver on new EDCs strategy
May 25, 2018 | MEPs and civil society representatives urged the European Commission on 24 May to act soon on defining a new strategy following the rejection by the European Parliament last autumn of its endocrine disruptor chemicals (EDC) definition.

EDC Criteria and next steps: A scientific perspective
May 24, 2018 | Presentation by Barbara Demeneix, BSc, PhD, DSc; Chair, Endocrine Society EU Task Force

European Parliament Briefing Showcases Society’s Thought Leadership on EDCs
May 24, 2018 | Endocrine Society member Barbara Demeneix, BSc, PhD, DSc, explained the importance of protecting the public from endocrine-disrupting chemical (EDC) exposure during a briefing for European Parliament members and staff in Brussels May 24.

Endocrine Society experts express concern with FDA statement on BPA safety
February 26, 2018 | The Endocrine Society today expressed disappointment with the U.S. Food and Drug Administration’s (FDA) statement asserting that the results of an interim report support previous determinations that bisphenol A (BPA) is safe for use in food containers and packaging.

Endocrine Society calls for improved guidance to identify endocrine-disrupting chemicals
February 1, 2018 | The Endocrine Society called for European regulators to ensure that endocrine-disrupting chemicals (EDCs) can be identified using practical, achievable scientific standards in detailed comments...…

EU vote to reject flawed EDC criteria creates opportunity to protect public health
October 4, 2017 | Endocrine Society eager to collaborate with EU lawmakers on science-based regulations.

Society Urges EU Parliament to be Transparent Around EDC Criteria
July 7, 2017 | Earlier this week, Member States of the European Union voted in favor of draft criteria to define endocrine-disrupting chemicals (EDCs). The Endocrine Society is extremely concerned that…

Endocrine Experts United in Disappointment with European Commission's Proposed Criteria on EDCs
June 16, 2017 | The Endocrine Society, the European Society for Endocrinology, and the European Society for Paediatric Endocrinology sent a joint letter to the European Commission expressing serious concern with the Commission’s proposed criteria on endocrine-disrupting chemicals (EDCs)…

Endocrine Society Applauds New Push to Regulate Chemicals in Personal Care Products
May 15, 2017 | The Endocrine Society praised the reintroduction of a Senate bill to ensure consumers are protected from hazards associated with exposure to chemicals in personal care products such as cosmetics and lotions…

Pyrethroid Pesticide Exposure Appears to Speed Puberty in Boys
April 1, 2017 | Environmental exposure to common pesticides may cause boys to reach sexual maturity earlier, researchers have found…

Exposure to BPA Substitute, BPS, Multiplies Breast Cancer Cells
April 1, 2017 | Bisphenol S (BPS), a substitute for the chemical bisphenol A (BPA) in the plastic industry, shows the potential for increasing the aggressiveness of breast cancer through its behavior as an endocrine-disrupting chemical…

Early-Life BPA Exposure Reprograms Gene Expression Linked to Fatty Liver Disease
April 1, 2017 | Exposure during infancy to the common plasticizer bisphenol A (BPA) “hijacks” and reprograms genes in the liver of newborn rats, leading to nonalcoholic fatty liver disease…

Exposure to Common Flame Retardants May Raise the Risk of Papillary Thyroid Cancer
April 1, 2017 | Some flame retardants used in many home products appear to be associated with the most common type of thyroid cancer, papillary thyroid cancer (PTC), according to a new study…

European Commission's Revised Proposal Limits Ability to Protect Public from Endocrine-Disrupting Chemicals
February 14, 2017 | The Endocrine Society expressed disappointment today in the European Commission's revised proposal on defining and identifying endocrine-disrupting chemicals (EDCs), citing unnecessarily narrow criteria for identifying EDCs…

Prenatal Bisphenol A Exposure Weakens Body's Fullness Cues
February 07, 2017 | An expectant mother’s exposure to the endocrine-disrupting chemical bisphenol A (BPA) can raise her offspring’s risk of obesity by reducing sensitivity to leptin, a hormone responsible for controlling appetite...

Chemical Exposure Linked to Lower Vitamin D Levels
September 20, 2016 | Endocrine-disrupting chemicals may alter active form of vitamin in body. Exposure to bisphenol A (BPA) and other endocrine-disrupting chemicals (EDCs) may reduce levels of vitamin D…

Introduction to Endocrine-Disrupting Chemicals:
A Guide for Public Interest Organizations and Policymakers

The Endocrine Society and IPEN developed this guide to raise global awareness about endocrine-disrupting chemicals (EDCs) by presenting a comprehensive picture of global exposures and health risks. The guide is available in several languages including:

Endocrine Society Position Statements
Position statements are official points of view or beliefs of the Endocrine Society. Statements are issued on scientific or medical issues related to endocrine research and practice in our effort to ensure policy decisions are based on the full body of available knowledge. Below are position statements related to endocrine-disrupting chemicals where we advocate for greater research and updated regulatory processes to affect positive change. You may also view our complete list of position statements.

Endocrine Society Policy Recommendations
The Society produces a range of alerts, letters to officials, and testimony transcripts in an ongoing effort to influence public policy related to research and clinical endocrinology issues.

Explore highlights of current publications across the Endocrine Society journals. Visit academic.oup.com/endocrinesociety for more.

Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to the Adipose Lineage
Endocrinology | July 14, 2017
Bassem M Shoucri, Eric S Martinez, Timothy J Abreo, Victor T Hung, Zdena Moosova, Toshi Shioda, and Bruce Blumberg
Undifferentiated mesenchymal stem cells are committed to the adipose lineage by activation of RXR but not PPARγ. This is mediated, in part, by a genome-wide reduction and redistribution of H3K27me3.

Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes
JCEM | March 9, 2017
Sheela Sathyanarayana, Samantha Butts, Christina Wang, Emily Barrett, Ruby Nguyen, Stephen M. Schwartz, Wren Haaland, Shanna H. Swan, and the TIDES Team
The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease…

Perinatal Exposure to Low-Dose Bisphenol-A Disrupts the Structural and Functional Development of the Hypothalamic Feeding Circuitry
Endocrinology | February 7, 2017
Harry MacKay, Zachary R. Patterson, and Alfonso Abizaid
Bisphenol-A (BPA) is a component of polycarbonate and other plastics to which humans are regularly exposed at low levels. BPA is characterized as an endocrine disruptor because of observations of its estrogenic activity…

Multi- and Transgenerational Consequences of Bisphenol A on Sexually Dimorphic Cell Populations in Mouse Brain
Endocrinology | November 14, 2016
Jessica A. Goldsby, Jennifer T. Wolstenholme, and Emilie F. Rissman
Bisphenol A (BPA) is an endocrine-disrupting compound used to manufacture plastics; it is present in linings of food cans, bottles, thermal receipts, and many other…

Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice
Endocrinology | September 1, 2016
Christopher D. Kassotis, John J. Bromfield, Kara C. Klemp, Chun-Xia Meng, Andrew Wolfe, R. Thomas Zoeller, Victoria D. Balise, Chiamaka J. Isiguzo, Donald E. Tillitt, and Susan C. Nagel
Unconventional oil and gas operations using hydraulic fracturing can contaminate surface and groundwater with endocrine-disrupting chemicals. We have previously shown that 23 of 24 commonly…

Minireview: Epigenomic Plasticity and Vulnerability to EDC Exposures
Molecular Endocrinology | August 1, 2016
Cheryl Lyn Walker
The epigenome undergoes significant remodeling during tissue and organ development, which coincides with a period of exquisite sensitivity to environmental exposures. In the case of…

Minireview: Endocrine Disruptors: Past Lessons and Future Directions
Molecular Endocrinology | July 19, 2016
Thaddeus T. Schug, Anne F. Johnson, Linda S. Birnbaum, Theo Colborn, Louis J. Guillette Jr., David P. Crews, Terry Collins, Ana M. Soto, Frederick S. vom Saal, John A. McLachlan, Carlos Sonnenschein, and Jerrold J. Heindel
Within the past few decades, the concept of endocrine-disrupting chemicals (EDCs) has risen from a position of total obscurity to become a focus of dialogue…

Female Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union
JCEM | April 1, 2016
Patricia A. Hunt, Sheela Sathyanarayana, Paul A. Fowler, and Leonardo Trasande
A growing body of evidence suggests that endocrine-disrupting chemicals (EDCs) contribute to female reproductive disorders. To calculate the associated combined health care and economic costs…

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
Endocrine Reviews | November 6, 2015
Andrea C. Gore, V. A. Chappell, S. E. Fenton, J. A. Flaws, A. Nadal, G. S. Prins, J. Toppari, and R. T. Zoeller
The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease…

Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk
JCEM | September 1, 2015
Suzanne E. Fenton and Linda S. Birnbaum
The role of the chemical environment in disease initiation or progression is becoming more evident. Endocrine disruption via environmental chemicals is now well documented in humans…

Prenatal Programming and Endocrinology
Endocrinology | August 4, 2015
Andrea C. Gore
The endocrine system is one of the body's interfaces with the environment, together with the nervous and immune systems. These interacting physiological units evolved…

Explore highlights of current education across the Endocrine Society.

ENDO 2017 Session
Endocrine Disrupting Chemicals: More Fracking Bad News

ENDO Session | No credit available
Chairs: Peter Ebeling, MBBS, Monash University and Jorma Toppari, MD, PhD, University of Turku

Endocrine Society's New EDC Scientific Statement: Do We Have a Critical Mass of Science?
ENDO Session | No credit available
Andrea C. Gore, PhD, University of Texas-Austin, Austin, TX

The Economic Costs of EDCs
ENDO Session | No credit available
Leonardo Trasande, MD, MPP, NYU School of Medicine, New York, NY

Contrasting Perspectives on EDCs from Different Science Domains: Regulatory Needs
ENDO Session | No credit available
David J. Dix, PhD, US Environmental Protection Agency, Washington, DC

Contrasting Perspectives on EDCs from Different Science Domains: Clinical Endocrinology
ENDO Session | No credit available
Jorma Toppari, MD, PhD, University of Turku, Turku, Finland

Contrasting Perspectives on EDCs from Different Science Domains - Basic Endocrinology
ENDO Session | No credit available
R. Thomas Zoeller, MS, PhD, Univ of Massachusetts, Amherst, MA

Epigenetic Basis of Mammary and Testicular Development: Interaction of Diet and Environmental Exposures
ENDO Session | No credit available
Shuk-Mei Ho, PhD, University of Cincinnati, Cincinnati, OH

EDC Whiteboard Animation
Watch an animated overview of endocrine-disrupting chemicals brought to you in collaboration with the Hormone Health Network.

Hormones and EDCs
What do you need to know about endocrine-disrupting chemicals (EDCs) and your body’s endocrine system? Learn about the impact of EDCs in this infographic and share with others.

The Five W’s of EDCs
Download and share this infographic on common questions about endocrine-disrupting chemicals.

EDCs Myth vs. Fact
There’s a lot of mixed information on endocrine-disrupting chemicals (EDCs). Visit the Hormone Health Network to learn about common myths of where EDCs can be found and how they can affect you.

Test Your Knowledge
What’s your score? Take this quiz to see what you do (and don’t) know about endocrine-disrupting chemicals (EDCs).

What Poisons Are in Your Body?
NY Times column on the chemicals in products we use every day.

Learn More