Reduced Adiponectin and Adiponectin to Resistin Ratio in Untreated Hyperthyroidism

Presentation Number: SAT-0550
Date of Presentation: June 21st, 2014

Kamal A S Al-Shoumer*1 and Vasanthy S Nair2
1Kuwait University/Faculty of Medicine, Division of Endocrinology, Safat, Kuwait, 2Faculty of Medicine, Kuwait University, Safat, Kuwait


INTRODUCTION:  Adiponectin and resistin are some of the recently discovered adipocytokines that participate in the regulation of intermediate metabolism. The aim of this study was to evaluate circulating levels of adiponectin and resistin in patients with thyroid hyperfunction and compare their levels with controls

SUBJECTS & METHODS:Twenty nine untreated hyperthyroid patients and 34 normal controls were studied. Patients and controls were matched for age, sex and body mass index. The subjects were assessed after an overnight fast and their blood was collected for measurement of adiponectin, resistin, glucose, insulin, intact proinsulin and thyroid function.

RESULTS:  Adiponectin level was significantly lower in untreated hyperthyroid patients than normal subjects (patients versus controls, mean±SEM, 2.04±0.27 vs. 2.73±0.39, p=0.049) whereas resistin level was similar in patients and controls. Fasting glucose (p=0.01), insulin (p=0.007), and intact proinsulin (p=0.02) were significantly higher in the patients than controls. Within the patients, adiponectin demonstrated a trend of negative correlation with free T3 (r = -0.35, p=0.08) and free T4 (r = -3.2, p=0.09).  However, the adiponectin to resistin ratio demonstrated stronger inverse relation with free T3 (r= -0.38, p=0.05) and with free T4 (r= -0.42, p=0.03). On the other hand, neither adiponectin, resistin nor adiponectin to resistin ratio were associated with TSH, age, BMI, fasting glucose, insulin or intact proinsulin.

CONCLUSION: Untreated hyperthyroidism is associated with reduction in adiponectin but normal resistin levels. Adiponectin and adiponectin to resistin ratio demonstrated inverse relation with thyroid status. It is possible that inadequate secretion of adiponectin plays a role in the adverse metabolic changes associated with hyperthyroidism.


Nothing to Disclose: KASA, VSN