Changes in Irisin Levels in Patients with Thyroid Function Impairment

Presentation Number: SAT-0566
Date of Presentation: June 21st, 2014

Marek Ruchala*1, Ariadna Zybek2 and Ewelina Szczepanek-Parulska2
1Poznan University of Medical Sciences, Poznan, Poland, 2Univ of Medical Sciences, Poznan, Poland


Irisin is a recently newly discovered peptide secreted by muscle and fat tissue that has significant influence on the body metabolism and thermogenesis. Irisin promotes a “browning” of subcutaneous white adipose tissue causing increased energy expenditure and heat production. Irisin may be potentially associated with the health-promoting role of physical exercises. Other, well-known factors that influence the metabolic state of the organism are thyroid hormones.

The aim of the study is to assess irisin and creatine kinase (CK) levels in patients affected by hypo- and hyperthyroidism.

A studied group of 20 patients newly diagnosed with thyroid function impairment was admitted to our department or outpatient clinic between July 2013 and January 2014. Routine clinical examination, laboratory tests (irisin, thyroid-stimulating hormone - TSH, free thyroxin – FT4 and triiodothyronine – FT3, and CK concentrations), thyroid ultrasound examination were performed in all cases. The difference between irisin level in hypo- and hyperthyroid patients was analyzed statistically, as well as the associations between irisin, TSH, free thyroid hormones and CK level.

The negative irisin and TSH level was correlated negatively (r = -0.4924, p=0.023), the irisin and FT4 level were correlated positively (r = 0.4833, p=0.036). CK level was negatively correlated with irisin, (r = -0,7272, p=0,014) FT4 (r = -0.9636, p=<0.0001) and FT3 concentrations (r = -0.8838, p= 0.0.0007). The mean serum irisin level was lower in hypothyroid than hyperthyroid patients, but the difference was at the border of statistical significance (p=0.0726).

The thyrometabolic state seems to influence the irisin serum concentration. Gathered data suggest that irisin level in patients with hypothyroidism is lower that with hyperthyroidism. Presented high CK level in hypothyroid patients indicated the possible role of muscle destruction in irisin level decrease.


Nothing to Disclose: MR, AZ, ES