Pain and Depression Score in African American Men with Prediabetes and Vitamin D Insufficiency

Presentation Number: SAT 330
Date of Presentation: April 2nd, 2016

Sana Khan*1, Hassan Zaidi2, Hiba Mohiuddin2, Arfana Akbar2 and Fahad Zaidi3
1University of Illinois at Chicago, Chicago, IL, 2Jesse Brown VAMC, Chicago, IL, 3Jesse Brown VA


Background: Randomized double-blind controlled studies suggest that there is a causative relationship between Vitamin D and musculoskeletal pain. Some studies indicate that Vitamin D is helpful for musculoskeletal pain and may lead to a faster decline of consecutive VAS scores and a decrease in the levels of inflammatory and pain related cytokines. There are no detailed reports of pain and depression score associations in African American men with Prediabetes and Vitamin D insufficiency.

Objective: The aim of this study was to assess an association of pain and depression in African American men with Prediabetes and Vitamin D insufficiency.   

Methods: A postal questionnaire was completed by African American male subjects ages 25-75 with Vitamin D intervention and Prediabetes at the VA. We collected pain score using McGill Pain Questionnaire and depression score using Beck’s Depression Inventory. Questionnaires included pain assesment (musculoskeletal pain and neuropathic pain), depression assessment, and clinical assessment (social factors (marital status, household population, income and education), diet, smoking, disease burden (Carlson), hypovitaminosis D [25(OH)D 5-29ng/ml], testosterone, BMI, age, PTH, and physical activity). A Regression analysis and ANOVA test was used to compare depression score and pain score dependent frequencies.

Results: A mean of 200 men (SD) were included into this analysis. Subjects were found to either be pain-free, have neuropathic pain, or musculoskeletal pain, and other did not meet a criteria for CWP (chronic widespread pain). There were three dependent paramaters for depression as well: BDI total score, cognative subscore, and somatic subscore. Respectively the subjects with musculoskeletal pain associated with lower 25-(OH)D levels while depression attenuated this relationship. CWP associated 50%.

Conclusion: These findings suggest that in the subject population of African American men with Prediabetes and low Vitamin D levels, pain remained moderately associated.


Nothing to Disclose: SK, HZ, HM, AA, FZ