Hyperparathyrodisim in Men - Low Morbidity and Mortality during 20 Years´Follow-up

Presentation Number: FRI 341
Date of Presentation: April 1st, 2016

Georgios Kontogeorgos*1, Christine Laine1, Lennart X Welin2, Michael Fu3, Per-Olof Hansson4 and Kerstin Landin-Wilhelmsen1
1Section for Endocrinology, Institution of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2Department of Medicine, Gothenburg, Sweden, 3Dept of Cardiology, Gothenburg, Sweden, 4Dept of Medicine, Gothenburg, Sweden


Objective: Normocalcemic, vitamin D sufficient hyperparathyroidism (nHPT) in men and women has been shown to have a benign course1. The aim was to study the prevalence and morbidity of nHPT and other parathyroid hormone (PTH) and calcium aberrations in 50-year-old men during 20 years´ follow-up.

Design: Cross-sectional and retrospective study at the Sahlgrenska University Hospital, Gothenburg, Sweden.

Subjects: A random population of 797 men born in 1943, was studied in 1993 (of whom 47% were vitamin D sufficient).

Measurements: A serum-(S) PTH >6.9 pmol/l was considered as HPT, S-calcium 2.15-2.49 mmol/l as normocalcemia, and S-25(OH)D >50 nmol/l as vitamin D sufficiency. Data on fractures, stroke and myocardial infarction were retrieved until 2013, yielding a 20-year follow-up.

Results: The prevalence of primary (p) HPT was 0.4% (one man with kidney stones; underwent parathyroid surgery), secondary HPT 0.3%, nHPT 2.7%, hypercalcemia with normal S-PTH 0.3%,  hypocalcemia with normal S-PTH 3.1%, and HPT with vitamin D insufficiency 5.5% in 1993 (age 50). Hypertension developed in all with pHPT. Hypertension was not more common in nHPT than in men without calcium/PTH aberrations during follow-up. No increase in fractures, diabetes, kidney stones (except for the man with pHPT), myocardial infarction, stroke, cancer or death was seen at follow-up.

Conclusions: Primary HPT was rare (0.4%), but normocalcemic, vitamin D sufficient HPT was common, 2.7%, in men aged 50 years. No increase in hard end points was seen in men with, compared with men without, calcium/PTH aberrations over a 20-year period.


Nothing to Disclose: GK, CL, LXW, MF, POH, KL