Exposure to the Chinese Famine in Early Life and the Risk of Osteoporosis in adulthood:a Prospective Study

Presentation Number: SUN 317
Date of Presentation: April 2nd, 2017

Gang Chen*1 and Liyao Zong2
1Fujian Provincial Hospital, Fuzhou, 2Fujian Provincial Hospital

Abstract

To assess association between famine exposure in early life and osteoporosis in adulthood in Chinese population.This prospective study was based on two communities in China. Our data of 2292 participants (1264 males and 1028 postmenopausal females) born between 1955 and 1965 were selected from a longitudinal (REACTION) baseline study in 2011. After 3 years, a follow-up in 2014 was conducted in the study. Calcaneus bone mineral density and bone quality were measure by quantitative ultrasound. The T-scores was used to assess BMD and the parameters of QUI, SOS and BUA were used to assess bone quality. Vertebral fracture was considered as a prospective height loss of 0.8 inches or more.Compared with non-exposed cohort, risks of osteoporosis for fetal-, early childhood-and mid-childhood famine exposed cohorts in postmenopausal women were significantly higher [adjusted OR: 3.741 (1.233, 11.44), P=0.021 vs 2.894(0.997, 8.571), P=0.055 vs 4.699 (1.622, 13.612), P=0.004], and it got no significant in men. Moreover, fetal exposed cohort had moderate negative relation with QUI [-5.07 (-10.226, 0.127), P=0.056] and BUA [-4.321(-0.88, 0.238), P=0.063]; early- and mid-childhood exposed cohorts had significantly inverse correlation with QUI [-7.085 (-11.799, -2.372) vs -10.845(-15.68, -6.01)] and BUA [ -6.381( -10.515, -2.246) vs -8.573(-12.815, -4.331)]. But all famine exposed cohorts had no significant relation with SOS.Exposure to famine in early life had adverse effects on bone quality and density. Famine exposure during early life was associated with higher risk of osteoporosis in adulthood, and this tendency is most obvious in postmenopausal women.

 

Nothing to Disclose: GC, LZ