The Niddk Information Network (dkNET) – a Community Resource and Information Portal That Promotes and Enhances Scientific Rigor and Reproducibility

Presentation Number: SH02-2
Date of Presentation: April 2nd, 2017

Ko-Wei Lin*, Anita E. Bandrowski, Michael Chiu, Fariba Fana, Tom Gillespie, James Go, Jamie Li, Yueling Li, Ibrahim Burak Ozyurt, Jeffrey S. Grethe and Maryann E. Martone
University of California San Diego, La Jolla, CA

Abstract

The NIDDK Information Network (dkNET; https://dknet.org) is an open community resource portal for basic and clinical investigators in diabetes, digestive, endocrine, metabolic, kidney, and urologic diseases. dkNET provides seamless access to a collection of diverse research resources, including data, information, materials, tools, funding opportunities, literature, services, events that advance the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

dkNET (1) is hosted on the SciCrunch (http://scicrunch.org) platform and makes it easy to find resources through a concept based search interface across NIDDK community and general biomedical resources, a resource registry with a curated catalog of thousands of research resources, and the Literature including PubMed and articles from Open Access literature. dkNET maintains unique databases targeted towards the NIDDK community, e.g., a database of pilot project funding opportunities available through many centers.

dkNET continues to be enhanced in response to user feedback and increased content. dkNET supports two types of users: basic researchers who are interested in finding new resources and also NIDDK-supported centers for which dkNET provides additional tools and services. New features include: 1) Notification alerts to keep up to date with the community, resources, or customized saved search; 2) Cross-reference information across data sources, e.g., for ClinicalTrails.gov data, users are provided information if a registered study has biosamples or a dataset deposited at the NIDDK central repository; 3) Links to archived data resources that are no longer in service; 4) Tools and services for resource-providers to utilize dkNETs content, including Application Programming Interfaces (APIs) and specialized analytics for tracking resource mentions in the literature.

One of the aims of dkNET is to promote research efficiency through scientific resource and data sharing and reuse. We’ve recently developed practical tools and infrastructure for complying with new NIH-guidelines to improve experimental rigor and transparency, in particularly with regards to validation requirements for key biological resources. dkNET supports a new standard for resource citation, Research Resource Identifiers (RRIDs), to ensure that reagents and tools are properly identified within published studies (2). RRIDs were recently endorsed and implemented by the journals of Endocrine Society as well as Elsevier, BMC, Frontiers, Cell Press, and Wiley. Through dkNET continuously updated data sources, researchers can obtain identifiers, check for problematic resources, and create an authentication plan suitable for grant submissions.

 

Nothing to Disclose: KWL, AEB, MC, FF, TG, JG, JL, YL, IBO, JSG, MEM