Depression Indicators Assessment in Acromegalic Patients

Presentation Number: SUN 463
Date of Presentation: April 2nd, 2017

Iago Renato Peixoto, Lia Silvia Kunzler and Luciana Ansaneli Naves*
University of Brasilia, Brasilia, Brazil


It is well known that acromegaly is a rare chronic degenerative disease that progresses with somatic changes in patients’ body and physiological functioning caused, in most cases, by growth hormone (GH) pituitary adenoma secretion. Concurrently, though, this affection also comes with alterations in patients’ psychological and cognitive functioning, in a way that recent studies have suggested a greater probability of developing depression, as well as a greater percentage regarding other affective psychological disorders or psychological symptoms, such as anxiety, neuroticism, negativism. Our study aimed to asses this heightened probability of developing depression by applying Beck’s Depression Inventory (BDI) on a sample of 23 acromegalic patients on outpatient follow-up in the neuroendocrinology outpatient facility of the HUB (Hospital Universitário de Brasília), as well as doing a medical chart revision. Fisher’s Exact Test, Student t-test and Pearson product-moment correlation coefficient were used to analyze discrete data, continuous data and correlation between the variables, respectively. The average BDI score was 12,7 ± 9,1, ranging from 0 to 30, in a way that 30,4% of the sample had an indicative of depression, taking into account the Manual da versão em Português das Escalas Beck (MPEB) cut-off score. Clinical and epidemiological features were compared to analyze statistical significance. No statistical significance was found regarding gender, mean age, disease activity, therapeutic modalities, serum values of IGF-1 (Insulin-like Growth Factor 1), ULNV values and adenoma diameter at MRI scan. It was observed, though, statistical significance comparing the mean diagnosis time (P < 0,05), considering the above mentioned cut-off score, as well as comparing the mean BDI of the 6-comorbidities group and the zero-comorbidity group (P < 0,05). These statistically significant results mentioned, as well as the increased prevalence of indicative of depression, especially compared to other chronic degenerative diseases (such as AIDS and Cancer) suggest that acromegalic patients are a population under an increased risk of developing depression, in a way that, within this population, an increased number of comorbidities and a recent diagnosis are associated with greater predisposition to the development of this psychological disorder.


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