Optic Neuritis As Presenting Complaint in Primary Hypoparathyroidism

Presentation Number: MON 298
Date of Presentation: April 3rd, 2017

Muhammad Fahad Arshad*1, Steven Kang2 and Nauman Arif Jadoon3
1DONCASTER ROYAL INFIRMARY, DONCASTER, UNITED KINGDOM, 2Doncaster Royal Infirmary, DONCASTER, United Kingdom, 3Hull Royal Infirmary, Hull


Background: Papilledema and raised intracranial pressure has been reported frequently in patients with hypoparathyroidism but very rarely optic neuritis (1).

Clinical case: We report a case of 63-year-old male who presented to ophthalmology with right sided visual loss and a relative afferent pupillary defect. He was diagnosed with optic neuritis and underwent MRI brain which showed bilateral white matter changes with the possibility of demyelination. He was initially diagnosed with relapsing-remitting multiple sclerosis by the neurologist but was later found to have severe hypocalcemia (adjusted calcium 1.32 mmol/L (2.20-2.60)) and idiopathic primary hypoparathyroidism (PTH <0.3 pg/ml (1.6-7.2)). Cerebrospinal fluid examination was entirely normal with negative oligoclonal bands. The initial MRI changes were thought to be secondary to severe hypocalcemia as per Neuroradiology MDT and subsequently, the diagnosis of multiple sclerosis was reversed. Although the underlying mechanism is not very clear, we believe there is an association between optic neuritis and primary hypoparathyroidism, especially in the absence of any other underlying cause for optic neuritis.

Conclusion: Although rare, but primary hypoparathyroidism can present as optic neuritis. Therefore, serum calcium should be checked in patients who present with optic neuritis, especially who have no obvious cause.


Nothing to Disclose: MFA, SK, NAJ