High Molecular Weight Adiponectin, Omentin-1 and Interleukin-6 in Early Pregnancy Are Associated with Later Development of Gestational Diabetes

Presentation Number: SAT 595
Date of Presentation: April 1st, 2017

Sally K. Abell*1, Soulmaz Shorakae1, Cheryce L Harrison1, Danielle Hiam2, Alba Moreno-Asso2, Nigel K. Stepto2, Barbora de Courten1 and Helena J. Teede1
1Monash University, Melbourne, Australia, 2Victoria University, Melbourne, Australia

Abstract

Background
Early prediction of Gestational Diabetes Mellitus (GDM) enables risk stratification of women, opportunities for prevention, and may improve pregnancy outcomes. Screening methods using clinical risk factors have reasonable predictive ability, but may be improved by combining biomarkers that precede the onset of hyperglycaemia.
Objective
We aimed to investigate the association of adipocytokines and other inflammatory markers in early pregnancy with development of GDM.
Methods
Adipocytokines and inflammatory markers were studied at 12-15 weeks gestation using biobanked serum control samples from a randomised trial of healthy lifestyle in pregnancy conducted in Melbourne, Australia. Study participants were identified as high risk for GDM based on an established validated clinical risk prediction tool (recruitment 2008-2010). Markers were tested using commercial ELISA kits for high molecular weight (HMW) adiponectin, interleukin-6 (IL-6), plasminogen activator inhibitor-1, visfatin, omentin-1, sex-hormone binding globulin (SHBG), monocyte chemoattractant protein and asymmetrical dimethylarginine. The association between each biomarker and development of GDM at 24-28weeks was evaluated using multivariable logistic regression analysis adjusted for maternal factors.
Results
The prevalence of GDM at our service during the study period was 8% (ADIPS 1998 criteria). There were 78 women with normal glucose tolerance and 25 women who developed GDM in the control group with serum for analysis. HMW adiponectin (adjusted odds ratio OR 0.37 [95% confidence interval 0.19-0.74]), omentin-1 (0.97[0.94-0.99]) and IL-6 (1.87[1.03-3.37]) were associated with development of GDM after adjustment for maternal factors age, body mass index and past history of GDM. Odds were also calculated for GDM using IADPSG criteria. Optimal levels were calculated to maximise odds of GDM in our study population. SHBG was negatively correlated with glucose measures on oral glucose tolerance test, however SHBG and other biomarkers were not associated with GDM development in multivariable regression analysis.
Conclusion
HMW adiponectin, omentin-1 and IL-6 may enhance sensitivity of early risk prediction tools for women at high risk of GDM. This may allow early identification and opportunities for prevention of GDM and adverse outcomes. Further research is required in large diagnostic validation studies to confirm these results.

Abbreviations: ADIPS – Australasian Diabetes in Pregnancy Society
IADPSG – International Association of Diabetes and Pregnancy Study Group

 

Nothing to Disclose: SKA, SS, CLH, DH, AM, NKS, BD, HJT