The Prevalence of Sleep Apnea Syndrome in Primary Aldosteronism

Presentation Number: SUN 407
Date of Presentation: April 2nd, 2017

Yoshitsugu Iwakura*1, Ryo Morimoto2, Masahiro Nezu2, Yuta Tezuka3, Yasuhiro Igarashi2, Masataka Kudo2, Hiromasa Ogawa4, Sadayoshi Ito2 and Fumitoshi Satoh3
1Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan, 2Tohoku University Hospital, Sendai, Japan, 3Tohoku University Graduate School of Medicine, Sendai, Japan, 4Tohoku University Hospital


Background: Primary aldosteronism (PA) is a major cause of secondary hypertension. Sleep apena syndrome (SAS) is also common contributing factor of hypertenison.

Some study reported the group with high risk of SAS had more frequent PA complication than that of low risk of SAS. On the other hand, there were few papers reported about continuous positive airway pressure (CPAP) implementation rate of the PA patients with SAS diagnosed by Polysomnography (PSG). Our study aim is to reveal the clinical characteristics and relationship of patients with PA and SAS.

Design and Method: Total 261 PA patients were enrolled. Systolic blood pressure (SBP), diastolic blood pressure (DBP), plasma aldosterone concentration (PAC), plasma renin activity (PRA), PAC/PRA ratio (ARR), after captopril chagllnging test of ARR (ARR-Cap), body mass index (BMI) and apnea hypopnea index (AHI) were mesured by apnomonitor®. The cases with high score of AHI and they got further investigation by PSG to decide application of CPAP.

Results: AHI was 31.4±1.8/hr (Average±SEM). 34 cases were diagnosed as mild SAS and 46 cases were diagnosed as severe SAS respectively. BMI was significantly correlated with AHI (r=0.3594, P<0.001). SBP: 149.6±1.2 mmHg, DBP: 94.2±0.9 mmHg, PAC: 32.0±1.8 ng/dl, PRA: 0.23±0.02 ng/ml/hr, ARR: 220.0±18.0 ng/dl per ng/ml/hr ARR-Cap: 141.3±14.1 ng/dl per ng/ml/hr were not significantly correlated with AHI.

Conclusions: This study showed high prevalence rate of SAS in PA patients. Screening with apnomonitor® and further investigation with PSG to detect complication of SAS in PA patients are clinically important.


Nothing to Disclose: YI, RM, MN, YT, YI, MK, HO, SI, FS