Pregnant Times and Diabetes in Postmenopausal Women without History of GDM

Presentation Number: SAT 591
Date of Presentation: April 1st, 2017

Chi Chen, Xiaomin Nie, Hualing Zhai, Yi Chen, Yingli Lu and Ningjian Wang*
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine


Background: It has been hypothesized that additional pregnancies may impair the ability of beta cell function to maintain normal glucose tolerance after pregnancy. However, previous studies had contradictory results. We aimed to measure whether pregnant times in child-bearing age were associated with diabetes in postmenopausal women with no history of GDM.

Methods: Our data source was the continuous National Health and Nutrition Examination Surveys 1999-2014. Eight thousand eight hundred and nine postmenopausal women over 40 years old who did not have a history of GDM were selected. Diabetes was defined according to American Diabetes Association 2014 criteria. Logistic regression analyses were used for the association of pregnant times with diabetes.

Results: Women with ≥4 pregnancies had significantly greater FPG (6.4±2.5 vs 6.0±1.7mmol/L), HbA1c (6.0±1.2 vs 5.8±1.0%), 2hPPG (7.8±3.3 vs 7.4±2.9) and HOMA-IR [2.72 (1.67-4.86) vs 2.52 (1.43-4.63)] than those with 2-3 pregnancies (all p <0.01). These women also had significantly higher prevalence of diabetes (27.9% vs 20.1%, p<0.001). Compared to women with 2-3 pregnancies, the adjusted ORs for diabetes were 1.108 (95%CI 0.893-1.374) for women who never got pregnant, 0.934 (0.752-1.161) for those with only one pregnancy, 1.157 (1.021-1.312) for those with more than or equal to 4 pregnancies after adjustment for age, race, educational level, annual household income, current drinking, smoking, BMI and physical activity.

Conclusion: ≥4 pregnancies in child-bearing age may be a potential risk factor for diabetes in postmenopausal women without history of GDM. Future longitudinal studies are warranted to confirm our finding.


Nothing to Disclose: CC, XN, HZ, YC, YL, NW