Vitamin D Status and Its Association with Parathyroid Hormone Concentrations in a Representative Population in Riyadh, Saudi Arabia

Presentation Number: SUN 344
Date of Presentation: April 2nd, 2017

Nasser Mohmmed Al-Daghri1, Majed S Alokail*1, Sobhy Yakout2, Naji J Aljohani3, Yousef Al-Saleh4 and Omar Al-Attas5
1Biomarkers Research Program, Riyadh, Saudi Arabia, 2King Saud University, Riyadh, 3King Saud bin Abdul-Aziz university, Riyadh, Saudi Arabia, 4King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, 5Prince Mutaib Chair for Biomarkers of Osteoporosis,

Abstract

The main objectives of this study were to evaluate vitamin D (25(OH)D) statues in Saudi adults in Riyadh area and its association with parathyroid hormone level with the purpose of determination the threshold for plasma 25(OH)D beyond which there is no more PTH suppression. 373 men and 720 women aged 50.7±13.9 years who randomly sampled from Riyadh were recruited in this study. Serum 25(OH)D, calcium, PTH and albumin concentration were measured. Vitamin D insufficiency (25–50 nmol/) prevalence was 57% and 42% in in males and females respectively. The prevalence of vitamin D deficiency (<25 nmol/L) was 72% and 27.5% in in males and females respectively. Increasing serum 25(OH)D concentrations leads to gradual decreasing of PTH in both sexes (p<0.001). However, no threshold of 25(OH)D at which PTH levels plateaued was observed. More studies elucidate 25(OH)D cut off in Saudi patients are needed.

 

Nothing to Disclose: NMA, MSA, SY, NJA, YA, OA