Effect of Vitamin D Supplementation on Depression Scores in Younger Caucasian and Africa-American Women

Presentation Number: SUN 345
Date of Presentation: April 2nd, 2017

Vinod Yalamanchili*1 and J Christopher Gallagher2
1Cheyenne Regional Medical Center, Cheyenne, WY, 2Creighton University Medical Center, Omaha, NE



Few observational studies found an association between vitamin D deficiency and depression in younger population but there are no systematic studies to support this.


We analyzed a randomized double blinded placebo controlled study involving 198 young women (119 Caucasian and 79 African American) with mean age 36.7 (±5.9) years, and vitamin D insufficiency (serum 25-hydroxyvitamin D ≤20 ng/dl [50 nmol/liter]). In this study subjects were randomized to placebo or to 400, 800, 1600, or 2400 IU of vitamin D3 daily. Calcium supplements were added to maintain a total calcium intake of 1000 to 1200mg daily. The Geriatric Depression Scale-Long Form 30(GDS-LF30) was used to collect data on depressive symptoms at baseline and at end of the study. Pearson’s correlation was used to find a relationship between baseline 25OHD level and depression scores. Multiple regression analysis was used to determine the effects of vitamin D dose and serum 25OHD, on depression scores adjusting for various baseline characteristics.


The mean GDS score at baseline and at the end were 5.3(SD±5.3) and 3.9(SD±4.1). The serum 25OHD levels at baseline did not correlate significantly with GDS scores (X2= -0.012, p=0.176). There was no effect of different doses of vitamin D on change in GDS score (p=0.453). There was no relationship between 12-month serum 25OHD level and 12-month depression scores (p=0.301). Only the baseline GDS scores were significantly related to 12-month GDS scores (p<0.0001).


In our study, treatment with incremental doses of vitamin D3 400 IU/d through 2400 IU/d in vitamin D insufficient younger women did not improve depression scores. In a previous 3-year study of 1,25 dihydroxyvitamin D and 1-year study of 25 dihydroxyvitamin D in elderly women there was no effect of treatment on GDS. It remains to be studied whether there is any effect of vitamin D3 supplementation in patients who have vitamin D insufficiency and depression.


Disclosure: JCG: , Bayer, Inc.. Nothing to Disclose: VY