Associations of Serum 25-Hydroxyvitamin D with Markers of Systemic Inflammation and the Influence of Adiposity

Presentation Number: SUN 330
Date of Presentation: April 2nd, 2017

Rachida Rafiq*1, Hassana El Haddaoui1, Reneé de Mutsert2, Frits R Rosendaal2, Pieter S Hiemstra2, Christa M Cobbaert2, Martin den Heijer1 and Renate T. de Jongh1
1VU University Medical Center, Amsterdam, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands


Background: Vitamin D is hypothesized to enhance antimicrobial defenses and decrease inflammation. The role of adiposity, associated with both vitamin D deficiency and inflammation, is unknown

Objective: To assess the relationship of serum 25-hydroxyvitamin D (25(OH)D) with markers of systemic inflammation (hsCRP, leptin, adiponectin) and elucidate the influence of adiposity therein.

Methods: We analysed data from The Netherlands Epidemiology of Obesity Study (NEO), a population-based prospective cohort study of men and women aged 45 to 65 years. Participants underwent several measurements including blood sampling, anthropometry and bio-impedance analysis. For this cross-sectional analysis we included data of participants with measurements of serum 25(OH)D, hsCRP, leptin and adiponectin (n=6630). In the regression analyses we corrected for age, sex, ethnicity, alcohol use, smoking status, physical activity, number of chronic diseases, season, total body fat and waist circumference.

Results: 20.4% of the participants were vitamin D deficient (serum 25(OH)D < 50nmol/L). Mean(sd) age and BMI were 55.7(6.0) years and 26.3(4.5)kg/m2, respectively. Ten nmol/L increase in serum 25(OH)D was associated with 2.3% (95%CI: 0.6 to 4.0) decrease in hsCRP, 2.4% (95%CI: 2.1 to 4.5) decrease in leptin, and 0.155 ng/mL (95%CI: 0.074 to 0.237) increase in adiponectin (adjusted for confounders, except for adiposity measures). After additional adjustment for total body fat and waist-circumference the associations for hsCRP and leptin largely disappeared: hsCRP +0.1% (95%CI: -1.6 to + 1.7); leptin: -6.7% (95%CI: -1.6 to +0.1). For adiponectin the relationship was attenuated, but still significant: 0.086 ng/mL (95%CI: 0 0.005 to 0.167).

Conclusion: Serum 25(OH)D was negatively associated with the pro-inflammatory markers hsCRP and leptin and positively associated with the anti-inflammatory marker adiponectin. This relationship is largely explained by the presence of adiposity.


Nothing to Disclose: RR, HE, RD, FRR, PSH, CMC, MD, RTD