Effects of Daily Vitamin D Supplementation on Respiratory Muscle Strength and Physical Performance in Vitamin D-Deficient COPD Patients: A Pilot Trial

Presentation Number: SUN 356
Date of Presentation: April 2nd, 2017

Rachida Rafiq*1, Henk-Jan Prins2, Wim G. Boersma2, J. (Hans) M.A. Daniëls1, Martin den Heijer1, Paul Lips1 and Renate T. de Jongh1
1VU University Medical Center, Amsterdam, Netherlands, 2NorthWest Hospital Group, Alkmaar, Netherlands


Introduction: Although vitamin D is well known for its function in calcium homeostasis and bone mineralisation, several studies have shown positive effects on muscle strength and physical function. In addition, vitamin D has been associated with pulmonary function and the incidence of airway infections. As vitamin D deficiency is highly prevalent in COPD patients, supplementation might have a beneficial effect in these patients.

Objective: To assess the effect of vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients. Secondary outcomes are pulmonary function, handgrip strength, exacerbation rate and quality of life.

Methods: We performed a randomised, double-blind, placebo-controlled pilot trial. Participants were randomly allocated to receive 1200 IU vitamin D3 per day (n=24) or a placebo (n=26) during 6 months. Study visits were conducted at baseline, at 3 and at 6 months after randomisation. During the visits blood was collected, respiratory muscle strength was measured (maximum inspiratory (MIP) and maximum expiratory pressure (MEP)). Physical performance and 6-minute walking tests were performed. Handgrip strength and pulmonary function were assessed. In addition, participants kept a diary card in which they registered respiratory symptoms.

Results: At baseline, both groups were vitamin D deficient (mean serum 25-hydroxyvitamin D (25(OH)D) in nmol/L(s.d.): 42.3(15.2) and 40.6(17.0) in the vitamin D and placebo-group, respectively). Participants with vitamin D supplementation had a larger increase in serum 25(OH)D compared to the placebo-group after 6 months (mean difference(s.d.):+ 52.8(29.8) vs. +12.3(25.1), p<0.001). Pulmonary muscle strength did not differ between the groups after 6 months. Also, no differences were found in physical performance and 6-minute walking test results, handgrip strength, pulmonary function, exacerbation rate or quality of life.

Conclusion: Vitamin D supplementation did not affect (respiratory) muscle strength or physical performance in this pilot trial in vitamin D-deficient COPD patients.


Nothing to Disclose: RR, HJP, WGB, JMAD, MD, PL, RTD