Effects of Fruit and Vegetable Intake on Bones: Systematic Review and Meta-Analysis

Presentation Number: SAT 331
Date of Presentation: April 1st, 2017

Melissa Orlandin Premaor*, Juliana Ebling Brondani, Liziane Maahs Flores and Fabio Vasconcellos Comim
Federal University of Santa Maria, Santa Maria, Brazil


Although fruits and vegetables appear to have a positive effect on bone markers and bone mineral density, its effect on fractures is yet to be established. This study aims to assess whether the intake of fruits and vegetables were associated with a decreased risk of bone fractures. We performed a systematic review of randomized controlled trials (RCTs) and cohort studies, whose protocol is registered with the International Prospective Register of Systematic Reviews (PROSPERO) under the number 2016: CRD42016041462. Studies that have evaluated the intake of fruit and vegetables, in women and men aged over 50 years and that reported the incidence of bone fractures as the outcome were included. The search strategy included the following descriptors: fruit; vegetables; vegetable products; bone and bones; bone fractures, postmenopausal osteoporosis e osteoporosis in the databases PubMed, BIREME, EMBASE and the Cochrane Library. Also, some studies were of selected based on the reference lists of the included articles. It was considered studies written in any language and with no publication date limits. The analysis of the studies was performed by two research members independently, discussed and agreed between both. In total 442 studies were found, of which 33 were duplicates. After the screening for the inclusion and exclusion criteria, seven studies remained. Of these, one was excluded due to no control group with usual diet, and the other was excluded due to redundant publication. Three cohort studies (Benetou et al., 2011; Langsetmo et al., 2011; Samieri et al., 2013) and one ECR (McTiernan et al., 2009) were included in the analysis. The meta-analysis was performed only in the cohort studies and HR (95% IC) of fracture was 0.9 (0,86 to 1,00), I² 21,6%. The HR and 95%IC of fracture in the ECR was 0,97 (0,92 to 1,02). In conclusion, a small number of studies were found, and there might be a trend in the reduction of the fracture risk with the intake of fruits and vegetables. More studies evaluating the impact of fruits and vegetable intake on fractures are needed.


Nothing to Disclose: MOP, JEB, LMF, FVC