Coffee Consumption and Serum Concentration of Inflammatory Markers: A Systematic Review

Presentation Number: SUN 578
Date of Presentation: April 2nd, 2017

Cicília Luiza Rocha dos Santos Paiva*1, Bruna Teles Soares Beserra2, Caio Eduardo Gonçalves Reis2, José Garrofe Dórea3, Teresa Helena Macedo da Costa3 and Angelica Amorim Amato2
1University of Brasília, Brasília, Brazil, 2University of Brasilia, Brasilia, Brazil, 3University of Brasilia, Brasília, Brazil

Abstract

Background: Coffee is rich in bioactive compounds reported to have antioxidant and anti-inflammatory actions. Regular coffee consumption has been associated with reduced risk of clinical conditions which share low-grade inflammation and oxidative stress, such as type 2 diabetes. It is currently not defined whether the effect of coffee on the inflammatory response depends on coffee type or the method used to prepare it, or if these effects depend upon baseline metabolic features, such as weight, adiposity or serum glucose levels. Thus, we conducted a systematic review addressing the effect of coffee or coffee components consumption on the serum concentration of inflammatory markers in adults with or without increased weight, waist circumference or glucose levels. Methods: Controlled clinical trials, either randomized or nonrandomized, that assessed the effect of coffee (caffeinated or decaffeinated), caffeine or another coffee component on inflammatory markers were searched using PubMed, Scopus, Web of Science and reference lists from inception to July 2016. Studies were eligible if the above-mentioned interventions were compared either to a control group (receiving placebo) or before and after the intervention (pre-post studies). Effective Public Health Practice Project (EPHPP) tool was used to assess the methodological quality of included studies. Results: After the analysis of the eligibility criteria, 15 articles (8 trials involving coffee and 7 caffeine) were included. Increased adiponectin levels were found in four out of seven trials comparing filtered coffee/caffeinated coffee with placebo or comparing medium roasted coffee/coffee with baseline. No change in adiponectin levels was seen in trials involving caffeine. None of the studies (n=5) that assessed the effects of coffee found changes in C-reactive protein (CPR) levels, but one out of three trials found decreased CPR levels in response to caffeine. Interleukin (IL)-6 was significantly increased by caffeinated coffee consumption compared to placebo in one out of four coffee trials, and in response to caffeine in three out of five caffeine studies. Caffeine was shown to increase IL-10 levels in two out of three caffeine trials. No changes in TNF-α levels were seen in coffee or caffeine trials. Six trials were rated as strong, whereas nine were rated as moderate, according EPHPP criteria. Conclusion: Data from the 15 studies included in this review suggested a predominant anti-inflammatory action of coffee consumption but not of caffeine, suggesting other coffee components may underlie this effect. The pro-inflammatory (increased IL-6 levels in most trials) and anti-inflammatory (increased IL-10 in most studies) seen in response to caffeine consumption point to the complex effects of this coffee component on the inflammatory response.

 

Nothing to Disclose: CLRDSP, BTSB, CEGR, JGD, THMD, AAA