The Prevalence of Diabetes in Women with Menopause Is Correlated with Previous Use of Oral Contraceptives at Child-Bearing Age

Presentation Number: SAT 590
Date of Presentation: April 1st, 2017

Jae Han Jeon*1, In-kyu Lee2, Keun-Gyu Park2 and Sung Woo Kim3
1Kyungpook National University School of Medicine, Daegu, Korea, Republic of (South), 2Kyungpook National University School of Medicine, 3GUMI CHA Medical Center

Abstract

It is hardly known whether use of oral contraceptives at child-bearing age may affect the onset of diabetes after menopause. Thus, we aimed to evaluate the association of past use of OCs with the development of diabetes and insulin resistance in post-menopausal women. This study was a cross-sectional study based on data from the Korea National Health and Nutrition Examination Survey carried out from 2007 to 2012. 6554 post-menopausal women were included in the analysis. The associations of OC use with the prevalence of diabetes in post-menopausal women were examined using multivariate logistic analysis. In addition, fasting glucose and insulin levels were measured in 3338
nondiabetic post-menopausal women, and the association between IR and OCs was examined by the analysis of covariance. The prevalence of diabetes was significantly
higher in post-menopausal participants who had taken OCs for more than 6 months than in those who had never taken OCs. In addition, the association remained significant after adjusting for multiple confounding factors (odd ratio 1.379; 95 % CI 1.115–1.707; P = 0.003). The duration of OC use was also positively associated with the prevalence of diabetes. Furthermore, taking OCs for more than 6 months led to a significant increase in fasting insulin levels and HOMA-IR in nondiabetic participants. Past use of OCs for more than 6 months led to a significant increase in the prevalence of diabetes in post-menopausal women, as well as an increase of IR in nondiabetic participants. These results suggest that the prolonged use of OCs at reproductive age might be an important risk factor for developing diabetes in postmenopausal women.

 

Nothing to Disclose: JHJ, IKL, KGP, SWK