Diabetic Neuropathy and Biochemical Parameters

Presentation Number: SAT 619
Date of Presentation: April 1st, 2017

Pinar Karakaya*1, Bahar Pehlivan2, Hamide Karagöz2 and Yildiz Okuturlar3
1Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, 2GENX PHARMACUTICALS, ISTANBUL, Turkey, 3Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey

Abstract

Introduction and Aim: Diabetic neuropathy (DN) is a widespread, distressing and the most common complication accompanying the high health costs of diabetes mellitus (DM). The major pathogenic hypotheses in the development of DN include multipathway activation, an increase in non-enzymatic glycosylation, vascular dysfunction, lipid metabolism compromise and impaired neurotropism. Clinically, several factors are implicated in the development of DN. The purpose of this study was to investigate the factors affecting the development of DN.

Method: One hundred patients, 50 with neuropathy and 50 without neuropathy, with type 2 DM, under monitoring at our hospital endocrinology and diabetes clinic, with duration of diabetes exceeding 5 years and agreeing to participate were included in the study. Patients’ demographic characteristics and biochemical parameters were examined. Microvascular complications were screened and fundus examinations were performed. Patients were assessed in terms of nephropathy, which was diagnosed using EMG.

Results: We investigated 100 patients, 67.5% of whom were women, 50 with neuropathy and 50 without neuropathy. Mean age of patients was 59.83±10.09 years, and mean duration of 10.2±5.79 years. In terms of treatments, 57.5% were using oral antidiabetics (OAD) and 42.5% were using insulin. At analysis of complications other than neuropathy, nephropathy was determined in 33.8% of the entire group and retinopathy findings in 36.3%. The characteristics of patients with or without DN were compared. No significant correlation was determined between the biochemical parameters fasting blood sugar (FBS), TSG or uric acid and presence of neuropathy (p>0.05). However, a significant relation was determined between urea levels and presence of neuropathy (p=0.012). This also applied to nephropathy in patients wıth neuropathy. A particularly significant relation was observed between age and duration of diabetes and presence of neuropathy, but there was no significant relationship in terms of age. HbA1clevels were also statistically significantly higher in patients with neuropathy. In terms of treatment, patients with DN were also those using more insulin. We attributed this difference to patients transferring to insulin therapy due to complicated DM.

Conclusion: When the demographic characteristics and biochemical parameters of patients with or without DN were compared in this study, advanced age, duration of diabetes and poorly regulated diabetes were associated with DN, but no significant relation was observed with other biochemical parameters. This shows that blood sugar regulation is of significant importance in the development of DN, one of the microvascular complications.

 

Nothing to Disclose: PK, BP, HK, YO