Cardiometabolic Risk Markers Are Associated with Soluble Receptor for Advanced Glycation End-Products in Adolescents with Obesity

Presentation Number: SAT 516
Date of Presentation: April 1st, 2017

Reyna Rodríguez Mortera*1, Claudia Luevano1, Sergio Solorio2, Russell Caccavello3, Alejandro Gugliucci3 and Ma Eugenia Garay-Sevilla1
1University of Guanajuato, Leon GTO, Mexico, 2Mexican Institute of Social Security, León, Mexico, 3Touro University, Vallejo, CA

Abstract

Obesity, dyslipidemia, hypertension and hyperglycemia are all well documented risk factors for cardiovascular disease. In adult populations some studies have also demonstrated that levels of plasma sRAGE are inversely correlated with the components of the metabolic syndrome (MetS), systemic arterial pressure, body mass index (BMI), waist-to-hip ratio, serum triglycerides (TG), and insulin resistance indexes. Endothelial function measured by FMD and arterial lesion by CIMT can serve as independent predictors of cardiovascular events. However, few studies have explored the relationship between sRAGE, and other cardiometabolic risk factors with obesity.

Objective: Study the association of sRAGE and cardiometabolic risk markers in lean adolescents vs adolescents with obesity

Material and Methods: We conducted a cross-sectional study in adolescents between 15-18 years old, 30 lean and 30 with obesity. Anthropometric measurements were evaluated using standard methods, flow-mediated vasodilation (FMD) and carotid intima media thickness (CIMT) were measured by ultrasound. We collected blood samples after a 12-hour fast to determinate lipid profile, ICAM, VCAM, and serum. We also calculated the atherogenic and TG/HDL index. The Ethical Committee of the Institution approved this study and informed consent was obtained from the participant adolescents and their parents.

Results: In the study group age was 16.8±1.4 y. In the group with obesity we found higher levels of VLDL-C (p<0.005), triglycerides (p<0.0001), atherogenic (p<0.0001), and TG/HDL index (p<0.0001), VCAM (p<0.01), sRAGE (p<0.002) and CIMT (p<0.019). No significant difference was found for FMD. CIMT correlated with BMI (p<0.02) and waist circumference (p<0.018); sRAGE correlated with BMI (p<0.001), waist circumference (p<0.002), hip circumference (p<0.003) and VCAM (p<0.001).

Conclusions: Serum sRAGE are lower in adolescents with obesity as compared to lean controls and they are associated not only with surrogate cardiometabolic risk factors but with early evidence of arterial lesion, as CIMT was significantly higher in this population. Our data show that obese adolescents without the metabolic syndrome already display metabolic and vascular alterations found in adults and support the contention that earlier dietary and lifestyle interventions are warranted.

 

Nothing to Disclose: RR, CL, SS, RC, AG, MEG