DHEAS Concentration during 25 – 55 Years in Men Was Higher As in Women in 1708 Patients Referred for DHEAS Assessment in an Outpatient Clinic

Presentation Number: SUN 418
Date of Presentation: April 2nd, 2017

Paulina Simaityte*1, Juste Baksanskaite1, Viktorija Bakstyte1, Tomas Kurakovas1, Rasa Steponaviciute2, Astra Vitkauskiene1, Vaidotas Urbanavicius3, Rytas Ostrauskas1 and Valentinas Matulevicius1
1Lithuanian University of Health Sciences, Kaunas, Lithuania, 2Lithuanian University of Health Sciences, Kaunas, Lithuania, 3Vilnius university Hospital Santariskiu clinics, Vilnius, Lithuania

Abstract

After studying Terzolo group early (1995, 1996) and later (2000, reference) reports on DHEAS-secreting adrenal tumours, we started our DHEAS determination-centered search for new cases. At the beginning we involved only women, but very soon we noticed that there are DHEAS concentration in blood differences between men and women in different ages.

Hypothesis of the current research was that analysing patients with high DHEAS concentration in serum will be the fastest way to describe more DHEAS-secreting tumours. Preliminary analysis showed that it is not always a case. Analysing also clinical symptoms, hormonal and imagine investigations we found that adrenal tumours may be found not only in women with hypersecretion of DHEAS, but also in men, in which some tumours manifested at low blood level of DHEAS. Consequently, study of DHEAS differences between men and women became pertinent.

Results of DHEAS assessment in 1708 consecutive cases, referred for DHEAS determination by endocrinologists and family doctors, were presented here: 1133 women (66.33%), 394 men (23.07%) and 181 children (10.60%). Women and girls were assessed during 2014, but men and boys – during 2014 and 2015 (because of rare referral for DHEAS in males). The concentration of DHEAS was expressed in micromoles per litre. Intra-assay precision CV% was 1.63-4.61. Inter-assay precision CV% was 3.66-5.8. Interval for detection was 0.01 – 30.1. For establishing normal ranges of DHEAS we counted Rmax (ratio max) and Rmin (ratio min) meanings. Rmax and Rmin represent age and gender adjusted results, related to maximal and minimal normal values indicated in assay kit for corresponding age of patients’ results.

In young (0 < 24 years ) and old (>55years) age there was no statistically significant difference between males and females. In contrary, during life span of 25- 34 , 35-44 and 45- 54 years blood level of DHEAS was statistically significantly higher in men than in women: {9.57(0.39) – {Mean (Standard deviation) vs. 8.13(0.55) µmol/l; p=0.004}, {8.04(4.36) vs. 5.96(3.47) µmol/l; p=0.001)} and {6.40(3.85) vs. 4.24(3.03) µmol/l; p=0.001)}, respectively. In additional analysis the pathological meanings of DHEAS (Rmax>1; Rmin<1) were eliminated to check if there is any influence of these high and low values to the result. Normal DHEAS group consisted of 1306 cases ( 936 female and 370 males). The results between genders in different ages were the same as in whole group. Results demonstrated that during 3 middle age decades DHEAS in men was constantly higher than in women.

We conclude, that DHEAS concentration during 25 – 55 years in men was higher as in women in 1708 patients referred for DHEAS assessment. DHEAS concentration in young patients (0-24years) and older ones (> 55 years) did not differ between males and females.We speculate that this phenomenon will complicate investigations of DHEAS and ageing even more.

 

Nothing to Disclose: PS, JB, VB, TK, RS, AV, VU, RO, VM