Estimated 10-Year Risk for Osteoporotic Fractures and Its Correlation with Risk for Cardiovascular Events in Asymptomatic Women

Presentation Number: SUN 314
Date of Presentation: April 2nd, 2017

Aili Lupita Garcia Tuomola*, Alain Sanchez Rodriguez, Natalie Madeline Atkinson Ginsburg and Joaquin Gerardo Joya Galeana
The American British Cowdray Medical Center, Mexico City, Mexico

Abstract

Title: Estimated 10-year risk for osteoporotic fractures and its correlation with risk for cardiovascular events in asymptomatic women.

Introduction: Hip fractures related to osteoporosis and cardiovascular events secondary to Atherosclerotic Cardiovascular Disease (ASCVD) are highly morbid conditions that frequently coexist in older women, however the prevalence of high-risk status for both disorders seen simultaneously in Mexican women remains unknown. Objective: To estimate the 10-year risk of fractures and cardiovascular events and the correlation between two validated risk scores for each condition. Methods: From January to November of 2016 we performed a cross-sectional study in asymptomatic women from a single center in Mexico City. Clinical, imaging and laboratory data was collected retrospectively from clinical records. The 10 year risk predicted equations applied for risk fracture and ASCVD were FRAX® tool and AHA/ACC 2013 risk equation, respectively. Results: Two hundred and six women with a mean age of 57.5 years (SD ± 10.3), Body Mass Index (BMI) 26.3 m/kg2 (SD ± 4.6); the 10-year risks for hip fracture and major fracture were 1.1% (95% CI = 0.87 – 1.32) and 4.5% (95% CI = 4.05 – 5.06), respectively; the 10-year ASCVD risk was 6.6% (CI 95% = 5.4 – 7.7. According to the conventional cutoff values for high risk patients the prevalence of high risk patients for hip fracture (> or = 3%) and ASCVD events (> or = 7.5%) were 12% (95% CI = 8.0 – 17.1) and 28.1% (95 CI = 21.9 - 34.3), respectively, none of the patients were at high risk for major fracture. The prevalence of high risk for both conditions was 9.71% (CI 95% = 5.6 - 13.7); the estimated correlation between the AHA/ACC 2013 score with FRAX® score for hip fracture (Pearson's r = 0.542, p < 0.001) and major fracture (Pearson's r = 0.602, p<0.001). Conclusions: Our findings suggest that a high risk for fractures and ASCVD coexist in a significant proportion of women from our center; additionally we found that good correlation is present for the 10-year estimated risks for both conditions.

Nothing to Disclose: ALGT, ASR, NMAG, JGJG

 

Nothing to Disclose: ALG, AS, NMA, JGJ