Leptin, Metabolic Syndrome, Nutritional Status, Sleep Duration and Shift Work Among Nursing Personnel

Presentation Number: LB SUN 68
Date of Presentation: April 2nd, 2017

Caio Holanda Limeira*1, Narriane Holanda2, Bruno Leandro Souza3, Nara Carvalho2, Cláudia Roberta Moreno4 and Elaine Cristina Marqueze5
1Potiguar University, Natal, Brazil, 2Federal University of Paraiba, João Pessoa, Brazil, 3Nova Esperança Medicine School, João Pessoa, Brazil, 4São Paulo University, São Paulo, Brazil, 5Catholic University, Santos, Brazil

Abstract

Background: Leptin seems to be closely associated with sleep, circadian timing system and cardiometabolic risk. Some studies point out that sleep deprivation are associated with an increased risk of obesity, diabetes and insulin resistance, and dysregulation of leptin, which negatively effect on human health. The aim of this study was to analyze the relationship between leptin level and metabolic syndrome, nutritional status as well as sleep duration and work shift among nursing personnel in a public hospital. Methods: A cross-sectional study, involving sixty nursing personnel (women) of a public hospital in Brazil, was conducted. The dependent variable was leptin level, and the independent variables were: metabolic syndrome (MS) (with MS and without MS, according IDF criteria), body mass index (BMI) (overweight BMI ≥ 25 kg/m2; normal BMI < 25 kg/m2), waist circumference (WC) (high WC > 80 cm; low WC ≤ 80 cm), sleep duration at work (short sleep ≤ 6 h/day; long sleep > 6 h/day) and work hours of the participants (only day shift; day/ night shift; ex-night shift). Results: The participants average age was 39.8 years old (SD=10.5 y/o). Prevalence of the metabolic syndrome, overweight (BMI), high WC and short duration sleep were 31.7%, 60%, 86.7% and 45%, respectively. The average leptin level in participants with MS was 4.7 ng/ml and 3.5 ng/ml for participants without MS (Mann-Whitney test p=0.55). We have also not found differences in leptin levels according to work hours (day shift=4.8 ng/ml; day/ night shift=4.3 ng/ml; ex-night shift=2.7 ng/ml – Kruskal Wallis p=0.97). On the other hand, leptin levels were different according to both measures of nutritional status, BMI (overweight BMI 5.7 ng/ml; normal BMI 1.2 ng/ml, Mann-Whitney test p<0.01) and WC (high WC 4.4 ng/ml and low WC 0.5 ng/ml, Mann-Whitney test p<0.01). There is a positive correlation between leptin levels and BMI (r=0.53, p<0.01), and also leptin levels and WC (r=0.58, p<0.01). There was no correlation between leptin levels and sleep duration (r=0.08, p=0.54). Conclusion: Although no hyperleptinemia has been found among the participants, there is clear evidence of the relationship of leptin and adiposity.

 

Nothing to Disclose: CHL, NH, BLS, NC, CRM, ECM