Association between calcaneus quantitative ultrasound (QUS) parameters and thyroid status in 2999 middle-aged and elderly Chinese: A population-based cross-sectional study

Presentation Number: SAT-251
Date of Presentation: June 15th, 2013

Tao Yang*, Yun Shi, Min Sun, Wei He, Yu Duan, Zhixiao Wang and Mei Zhang
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China


Aim: Although it is generally accepted that thyroid hormones affect bone metabolism, there is a dearth of data on the association of thyroid antibodies with bone status.Objective: We aim to investigate the association between thyroid antibodies or hormones and quantitative ultrasound (QUS) parameters; to determine the effect of thyroid antibodies or hormones on osteoporotic fracture susceptibility.Design and setting: This was a cross-sectional, population-based study performanced in Nanjing,China.Participants: A total of 2999 Chinese adults aged 40-75 years participated.Main Outcome Measures: We measured free T3 (fT3) (pmol/l), free T4 (fT4) (pmol/l), TSH (uIU/ml),anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-Tg), 25-hydroxyvitamin D (25 OHD),QUS and collected demography data including fracture history.Results: After adjustment for potential confounders, males with higher titer of anti-TPO(≥200IU/ml)had lower QUS parameters than controls(<40IU/ml) (p<0.05), this trend was consistent with the 25OHD level (41.93±10.01nmol/l vs. 46.99±15.09nmol/l, p=0.004). QUS values decreased across the lowest to highest tertiles of fT4 in men and premenopausal women (p<0.05); lower fT3 was significantly associated with increased odds of osteoporotic fracture among postmenopausal women (odds ratio 3.329; 95% confidence interval 1.800-6.155; p=0.001). The incidence of osteoporotic fracture was not affected by thyroid antibodies.Conclusion: It suggests an awareness of the need to screen men with higher titer of anti-TPO for the presence of osteoporosis. The correlation between thyroid hormones and osteoporosis or osteoporotic fracture is complex. Further prospective studies are expected to elucidate the precise relationship between thyroid status and osteoporosis or fracture.


Nothing to Disclose: TY, YS, MS, WH, YD, ZW, MZ