Adrenal Tumors: Novel Causes and Mechanisms


Macronodular Adrenal Hyperplasia Due to Mutations in an Armadillo Repeat Containing 5 (ARMC5) Gene: A Clinical and Genetic Investigation
Mihail Zilbermint, Fabio R Faucz, Maya Beth Lodish, Eva Szarek, Giampaolo Trivellin, Ninet Sinaii, Rossella Libe, Guillaume Assie, Stéphanie Espiard, Ludivine Drougat, Bruno Ragazzon, Jerome Yves Bertherat and Constantine A Stratakis


β-Estradiol (E2) Stimulates Cortisol Secretion in Primary Pigmented Nodular Adrenal Disease: An Explanation for the Increased Frequency of Cushing's Syndrome in Female Patients with Carney Complex
Zakariae Bram, Julien Wils, Bruno Ragazzon, Marthe Risk-Rabin, Rossella Libe, Jacques Young, Marie-Christine Vantyghem, Antoine Martinez, Constantine A Stratakis, Jerome Yves Bertherat, Herve Lefebvre and Estelle Louiset


Constitutive Activation of Prkaca in Adrenal Cushing's Syndrome
Felix Beuschlein, Martin Fassnacht, Guillaume Assie, Davide Calebiro, Constantine A Stratakis, Andrea Osswald, Cristina Lucia Ronchi, Thomas Wieland, Silviu Sbiera, Fabio R Faucz, Kathrin Schaak, Anett Schmittfull, Thomas Schwarzmayr, Olivia Barreau, Delphine Vezzosi, Marthe Rizk-Rabbin, Ulrike Zabel, Eva Szarek, Paraskevi Salpea, Antonella Forlino, Annalisa Vetro, Orsetta Zuffardi, Caroline Kisker, Susanne Diener, Thomas Meitinger, Martin Lohse, Martin Reincke, Jerome Yves Bertherat, Tim M. Strom and Bruno Allolio


The Stem Cell Gene LGR5 Is the Most Specific Marker of Human Adrenal Zona Glomerulosa, and May be the Driver of Adrenal Zonation through Non-Canonical Wnt Activation
Lalarukh Haris Shaikh, Ada ED Teo, Grahame McKenzie, Junhua Zhou, Sudeshna G Neogi, Ian McFarlane, Nichola Figg, Elena AB Azizan, Anthony P Davenport and Morris J Brown


ATR-101, a Selective ACAT1 Inhibitor in Development for Adrenocortical Carcinoma, Disrupts Steroidogenesis and Causes Apoptosis in Normal Canine Adrenals
Marc B Bailie, Martin D Phillips, Raili Kerppola, James R Herman, Paul G Pearson, Gary D Hammer, Randall W Whitcomb, Julia Owens and Stephen W Hunt III