From Genetics to Clinical Trials in Pituitary Disease

OR17-1

Population Screening for the Irish Founder AIP Mutation R304* Reveals a Prevalence of 1/500 in the Local Population, While High Mutation Frequency Is Present Among Irish Familial and Sporadic Somatotropinoma Patients
Serban Radian, Plamena Gabrovska, Brendan Holland, Helen Wallace, Anthony W Ryan, Karen McGurren, Karen Stals, Anna-Marie Bussell, Mark G Thomas, Aidan Holland, Elena Daniela Aflorei, Sayka Barry, Craig E Stiles, Ida Pernicova, Giampaolo Trivellin, Judit Dénes, Maria Herincs, Laura C. Hernandez Ramirez, Jade Samuels, Ronan McCloskey, Michal Azjensztejn, Noina Abid, Ajith V Kumar, Brew A Atkinson, Sian Ellard, Ross McManus, Chris J Thompson, Gerard J Linden, Lisa Bradley, Amar Agha, Steven J Hunter, Patrick J. Morrison and Márta Korbonits

OR17-2

OR17-3

Mechanisms of Mammalian STE20-like Kinase 4 (MST4) to Promote Pituitary Tumor Cell Survival and Proliferation Under Hypoxic Conditions
Weipeng Xiong, Mei Xu, Katja Kiseljak-Vassiliades, Sean Colgan, Kelley S Brodsky, Holger Eltzschig, Bette K Kleinschmidt-Demasters, Kevin Lillehei and Margaret E Wierman

OR17-4

LCI699, a Potent 11β-Hydroxylase Inhibitor, Normalizes Urinary Free Cortisol Levels in Patients with Cushing's Disease: 22-Week, Multicenter, Open-Label Study
Rosario Pivonello, Maria Fleseriu, Jacques Young, Xavier Bertagna, Amir H Hamrahian, Mark E Molitch, Chikara Shimizu, Tomoaki Tanaka, Akira Shimatsu, Tracy White, Annie Hilliard, Chuan Tian, Nicholas Sauter and Beverly MK Biller

OR17-5

Efficacy and Safety of Oral Octreotide in Acromegaly: Results of a Multicenter Phase III Trial in 155 Patients
S Melmed, V Popovic-Brkic, Martin Bidlingmaier, M Mercado, AJ van der Lely, N R Biermasz, M Bolanowski, M Coculescu, J Schopohl, K Racz, B Glaser, M I Goth, Y Greenman, P J Trainer, E Mezosi, I Shimon, A Giustina, D L Kleinberg, S L Teichman, R Mamluk, A Haviv and C J Strasburger