Podcast Journal Club

MACS and Vertebral Fractures

September 18, 2025

EFL065

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For our 65th episode, we return to The Journal of Clinical Endocrinology & Metabolism to look at a report of two different studies that investigate the relationship between MACS (mild autonomous cortisol secretion) and vertebral fractures. MACS has been of increasing interest to endocrinologists over the past few years, with a greater recognition of its health impact and new guidelines on its assessment and treatment. As this topic continues to evolve, we thought that this paper has a high likelihood of impacting our clinical care and so is well worth discussion. Host Chase Hendrickson, MD, from Vanderbilt University talks with regular contributor Jill Wagoner, MD, from the University of Nebraska Medical Center, and guest expert Oksana Hamidi, DO, from the University of Texas Southwestern Medical Center. They discuss “Adrenalectomy Reduces the Risk of Vertebral Fractures in Patients With Mild Autonomous Cortisol Secretion” by Morelli et al, first published online in JCEM in April 2025.

Meet the Speakers

Oksana Hamidi and Jill Wagoner

Oksana Hamidi, DO, MSCS, is an associate professor of internal medicine at University of Texas Southwestern Medical Center in Dallas and a nationally recognized expert in adrenal disorders. Her work focuses on the pathophysiology and management of mild autonomous cortisol secretion and adrenal tumors. She leads multidisciplinary care for adrenal nodules, contributes to international guidelines, and has authored more than 40 peer-reviewed publications. As a principal investigator in clinical trials and a frequent invited speaker, Dr. Hamidi combines research, education, and patient care to advance adrenal medicine.

Jill Wagoner, MD, is a staff endocrinologist for the University of Nebraska Medical Center in Omaha. She attended the University of Nebraska Medical Center, where she attained her medical degree, internal residency training, and a year as chief resident. Dr. Wagoner attended fellowship at University of Colorado Anschutz Medical Campus and chose to stay on as faculty, focusing on general endocrinology and medical education. She was the lead faculty coordinator for her Endocrine Explained ECHO series and worked as endocrine director of house staff and student education. Since fall 2024, she has transitioned her faculty appointment from University of Colorado back to University of Nebraska with hopes to continue focus on medical education.

Resources


Meet the Host

Chase HendricksonChase Hendrickson, MD, MPH, practices general endocrinology at the Vanderbilt University Medical Center, where he is an associate program director for the endocrinology fellowship program. His interests include endocrine education, teaching inferential methods, and quality improvement.


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