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Endocrine Society Signs Joint Letter Opposing HHS's Draft Enforcement Discretion Policy Regarding 503A Compounding Using Certain Peptide Bulk Drug Substances

November 13, 2026

Dear Secretary Kennedy:
We, the undersigned physicians, nurses, and other health care professionals, strongly oppose the Department of Health and Human Services (HHS) draft enforcement discretion policy permitting the compounding of six non-FDA-approved injectable peptides. This policy risks exposing patients to contaminated injections, dangerous dosing errors, and inadequately studied treatments while placing additional demands on an already strained health care system.

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