Women's Health SIG

Bone Health During the Perimenopausal Transition

Date: December 2, 2025

Moderators:

• Susan Tibuni-Sanders, MD, Kaiser Permanente, San Francisco, Chair of Women's Health SIG
• Muriel Babey, MD, Assistant Professor of Medicine, Adjunct, University of California, San Francisco, Co-Chair of Bone and Mineral SIG

Speakers:

• Maria Schuller Almeida, PhD, Professor, Departments of Internal Medicine and Orthopedic Surgery, Associate Director, Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences
• Amanda L Clark, MD, MCR, MSCP, Professor Emeritam, Urogynecology and Reconstructive Pelvic Surgery, Obstetrics and Gynecology, Oregon Health & Science University
• Mark Bolland, MD, Associate Professor, Faculty of Medical and Health Sciences, Medicine, University of Auckland, New Zealand

Description:

This webinar will examine bone health during the perimenopausal transition, a critical window of accelerated bone loss and skeletal adaptation. Presentations will review the hormonal and cellular mechanisms underlying perimenopausal bone loss, clinical approaches to assessment and prevention, and recent evidence from trials evaluating zoledronic acid for bone preservation.

Each presentation will last approximately 25 minutes, followed by a 5-minute question-and-answer session.

Learning Objectives:

Upon completion of this activity, participants will be able to:

1. Examine the basic and translational mechanisms driving bone loss during the perimenopausal transition.
2. Discuss clinical strategies for assessing, monitoring, and maintaining bone health during this period.
3. Understand the design and outcomes of the 5-yearly zoledronic acid trial and its implications for bone preservation.

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