BoneDiscover Updates in New and Emerging Therapies

Sessions, journal articles, and point of care tools highlight the molecular discoveries and evolving treatment options for rare metabolic bone diseases and osteoporosis in patients of all ages.

Researchers Recommend Specific Diabetes Medications to Protect Bone Health
June 21, 2017 | Type 2 diabetes (T2D) and osteoporosis often coexist in patients, but managing both conditions can be a challenge. A comprehensive review published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism highlights…

Hidden Fissures: Hip Fracture Rates End Years-Long Decline
May 1, 2017 | The U.S. and other developed countries have made steady progress in recent years in bringing down the rate of hip fractures in the elderly…

Disrupted Stress Hormone Signals in Bone Cells Protect from Diet-Induced Obesity
April 4, 2017 | A high-calorie diet, even without a high amount of fat, causes bone loss, and both high-calorie and high-fat diets induce excessive fat gain and insulin resistance…

New Measurement Technique Lowers Estimated Vitamin D Recommended Daily Allowance
April 2, 2017 | After re-measurement of vitamin D by improved technology, the Recommended Dietary Allowance (RDA) for vitamin D intake drops from 800 to 400…

Prolonged Sleep Disturbance Can Lead to Lower Bone Formation
April 1, 2017 | Insufficient sleep, a common problem that has been linked to chronic disease risk, might also be an unrecognized risk factor for bone loss. Results of a new study…

Menopausal Hormone Therapy Improves Bone Health
November 17, 2016 | Study reveals bone density, structure benefits persist after treatment ends. Women who undergo hormone therapy for menopausal symptoms such as hot flashes can not only increase…

Customized Vitamin D Supplements May Benefit Pregnant Women
October 27, 2016 | Doses can be tailored to compensate for individual risk factors, protect bone health. Individualized supplement doses help protect pregnant women from vitamin D deficiency, according…

Chemical Exposure Linked to Lower Vitamin D Levels
September 20, 2016 | Endocrine-disrupting chemicals may alter active form of vitamin in body. Exposure to bisphenol A (BPA) and other endocrine-disrupting chemicals (EDCs) may reduce levels of vitamin D…

Explore highlights of current education across the Endocrine Society.

How to Assess Second-Line Diabetes Agents for Patients at Risk for Major Osteoporotic Fractures
CME Activity | 0.5 AMA PRA Category 1 Credits™
Author: Doron Schneider, MD, FACP; Ann Schwartz, PhD, MPH
What are the best ways to help prevent your type 2 diabetes patient from avoiding major osteoporotic fractures? This interactive case study features can exploration of current science, clinical recommendations and medication options. The case study provides insights into mitigating fracture risk while effectively treating type 2 diabetes.

Case-Based Update on Hypoparathyroidism
CEU Satellite Symposium | 2.0 AMA PRA Category 1 Credits™
Chair: Steven T. Harris, MD
Faculty: Susan M. Ott, MD; Lynn A. Kohlmeier, MD; and Nelson B. Watts, MD
Weigh the traditional and contemporary treatment options with discussions on diagnostic and etiology.

Hypophosphatasia: New Options in the Management of Alkaline Phosphatase Deficiency
ENDO Satellite Symposium | 2.0 AMA PRA Category 1 Credits™ and ABIM MOC Part 2 points
Chair: Jill H. Simmons, MD
Faculty: Nancy S. Dunbar, MD, MPH; Peter J. Tebben, MD; and Michael P. Whyte, MD
What does low alkaline phosphatase mean in practice? Recognize subtle signs of HPP in pediatric and adult patients and learn about the most recent treatment approvals.

New Frontiers in Osteoporosis: Targets in Bone Remodeling
ENDO Satellite Symposium | 2.0 AMA PRA Category 1 Credits™ and ABIM MOC Part 2 points
Chair: Michael R. McClung, MD
Faculty: Paul D. Miller, MD; Bente Lomholt Langdahl, PhD, DMSc; and Benjamin Zev Leder, MD
Keep up to date on the latest trials and emerging treatments in this rapidly evolving field.

Hypoparathyroidism @Point of Care
Practice Resource | Credit available
Find practical information when you need it the most to recognize signs, interpret results, and guide treatment decisions.

Osteoporosis @Point of Care
Practice Resource | Credit available
Find practical information when you need it the most to recognize signs, interpret results, and guide treatment decisions.

Endocrine Facts & Figures: Bone and Mineral
Research Resource | No credit available
Advisory Panel Chair: Robert A. Vigersky, MD
Updated epidemiological data and in-depth discussion on disorders of bone and mineral metabolism with current citations and expert insights.

Explore highlights of current publications across the Endocrine Society journals. Visit for more.

Percutaneous Transsternal Cryoablation of Ectopic Parathyroid Adenoma in the Anterior Mediastinum
JES | September 11, 2017
James Meek, Savannah Fletcher, Marcus Kessler, Aparna Komarraju, Cordell Privat, and Mary Meek
This study describes two cases that involve the successful use of percutaneous transsternal cryoablation to treat ectopic parathyroid adenomas located in the anterior mediastinum.

Hypocalciuria as a Predictor of Reduced Intestinal Calcium Absorption
JES | August 7, 2017
Preaw Hanseree, Abigail C. Staples, Vincent L. Cryns, and Karen E. Hansen
Adequate intestinal calcium absorption is crucial for bone mineralization and calcium homeostasis. Calcium absorption is influenced by numerous factors…

Vitamin D Stored in Fat Tissue During a 5-Year Intervention Affects Serum 25-Hydroxyvitamin D Levels the Following Year
JCEM | July 26, 2017
Ieva Martinaityte, Elena Kamycheva, Allan Didriksen, Jette Jakobsen, and Rolf Jorde
In this study, we explored the effects after high-dose vitamin D supplementation. We found that 25(OH)D and vitamin D stored in fat contributed to higher serum 25(OH)D values in 12 months.

Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice
Endocrinology | July 12, 2017
Linh Ho, Liping Wang, Theresa M. Roth, Yong Pan, Eric M. Verdin, Edward C. Hsiao, and Robert A. Nissenson
Bone resorption and formation are tightly coupled through systemic and local regulation. A wave of bone formation follows each cycle of bone resorption to maintain skeletal…

Energy Metabolism of the Osteoblast: Implications for Osteoporosis
Endocrine Reviews | May 1, 2017
Wen-Chih Lee, Anyonya R. Guntur, Fanxin Long, and Clifford J. Rosen
Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and maintenance of the skeleton. Clinical disorders of substrate availability (e.g., diabetes mellitus, anorexia nervosa…

Calcium and Bone Turnover Markers in Acromegaly: A Prospective, Controlled Study
JCEM | April 12, 2017
Tina Constantin, Vin Tangpricha, Reshma Shah, Nelson M. Oyesiku, Octavian C. Ioachimescu, James Ritchie, and Adriana G. Ioachimescu
Some acromegaly patients exhibit hypercalcemia or hypercalciuria. The etiology of hypercalcemia includes primary hyperparathyroidism or 1,25-dihydroxy-vitamin D [1,25(OH)2D] excess. Studies in patients …

Primary Aldosteronism as a Risk Factor for Vertebral Fracture
JCEM | February 09, 2017
Masakazu Notsu, Mika Yamauchi, Masahiro Yamamoto, Kiyoko Nawata, and Toshitsugu Sugimoto
Some observational studies have revealed an association between excessive aldosterone levels and reduced bone mineral density…

Skeletal Complications and Mortality in Thyroid Cancer: A Population-Based Study
JCEM | January 25, 2017
Palak Choksi, Maria Papaleontiou, Cui Guo, Francis Worden, Mousumi Banerjee, and Megan Haymart
Although bone is a common site for tumor metastases, the burden of bone events [bone metastases and skeletal-related events (SREs)] in patients with thyroid cancer is not well known…

Acute Parathyroid Hormone Injection Increases C-Terminal but Not Intact Fibroblast Growth Factor 23 Levels
Endocrinology | January 23, 2017
Vanessa M. Knab, Braden Corbin, Olena Andrukhova, Julia M. Hum, Pu Ni, Seham Rabadi, Akira Maeda, Kenneth E. White, Reinhold G. Erben, Harald Juppner, and Marta Christov
Fibroblast growth factor 23 (FGF23) is a bone-derived hormone regulating phosphate excretion and vitamin D activation in the kidney…

Fibroblast Growth Factor 23, Mineral Metabolism, and Adiposity in Normal Kidney Function
JCEM | January 17, 2017
Sarah Zaheer, Ian H. de Boer, Matthew Allison, Jenifer M. Brown, Bruce M. Psaty, Cassianne Robinson-Cohen, Erin D. Michos, Joachim H. Ix, Bryan Kestenbaum, David Siscovick, and Anand Vaidya
Obesity is associated with poor bone mineralization and quality. Fibroblast growth factor 23 (FGF23) plays an important role in skeletal physiology…

Influence of Premature Mortality on the Link Between Type 2 Diabetes and Hip Fracture: The Fremantle Diabetes Study
JCEM | November 23, 2016
Emma Hamilton, Wendy A. Davis, David G. Bruce, and Timothy M. E. Davis
There is consistent evidence that type 2 diabetes is associated with an increased incidence of hip fracture…

Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation during Pregnancy
JCEM | October 28, 2016
Rebecca J. Moon, Nicholas C. Harvey, Cyrus Cooper, Stefania D'Angelo, Sarah R. Crozier, Hazel M. Inskip, Inez Schoenmakers, Ann Prentice, Nigel K. Arden, Nicholas J. Bishop, Andrew Carr, Elaine M. Dennison, Richard Eastell, Robert Fraser, Saurabh V. Gandhi, Keith M. Godfrey, Stephen Kennedy, M. Zulf Mughal, Aris T. Papageorghiou, David M. Reid, Sian M. Robinson, and M. Kassim Javaid
Context: Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. Objective: We assessed which maternal and…

For a complete list of Endocrine Society guidelines, visit

Paget's Disease of Bone
JCEM | November 19, 2014
Frederick R. Singer, Henry G. Bone III, David J. Hosking, Kenneth W. Lyles, Mohammad Hassan Murad, Ian R. Reid, and Ethel S. Siris
We recommend that plain radiographs be obtained of the pertinent regions of the skeleton in patients with suspected Paget's disease. If the diagnosis is confirmed…

Osteoporosis in Men
JCEM | July 02, 2013
Nelson B. Watts, Robert A. Adler, John P. Bilezikian, Matthew T. Drake, Richard Eastell, Eric S. Orwoll, and Joel S. Finkelstein
Osteoporosis in men causes significant morbidity and mortality. We recommend testing higher risk men [aged 70 and men aged 50–69 who have risk factors…

Evaluation, Treatment, and Prevention of Vitamin D Deficiency
JCEM | June 06, 2011
Michael F. Holick, Neil C. Binkley, Heike A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P. Heaney, M. Hassan Murad, and Connie M. Weaver
Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recommended supplementation at…

For additional meetings, visit the Endocrine Society's Worldwide Endocrinology Calendar at

World Congress on Osteoporosis Osteoarthritis and Musculoskeletal Diseases
Dates: April 19-22, 2018
Sponsor: European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and International Osteoporosis Foundation (IOF)
Location: Krakow, Poland

45th European Calcified Tissue Society Congress
Dates: May 26–29, 2018
Sponsor: European Calcified Tissue Society
Location: Valencia, Spain

Novel Aspects of Bone Biology
Dates: June 13-16, 2018
Sponsor: Keystone Symposia on Molecular and Cellular Biology
Location: Snowbird, Utah, United States