Female ReproAdvancing Research and Ensuring Reproductive Health

Explore recent research and guidelines on factors impacting fertility, reproductive health, and aging in women.

Experts issue recommendations to provide gender-affirmation treatment for transgender individuals
September 13, 2017 | The Endocrine Society today issued a Clinical Practice Guideline on the treatment for gender-dysphoric/gender-incongruent people, commonly referred to as transgender, to develop the physical characteristics of the affirmed gender…

Researchers reveal link between PCOS, type 2 diabetes
August 29, 2017 | Women who have polycystic ovary syndrome (PCOS) have a higher risk of developing type 2 diabetes (T2D) and are diagnosed at an earlier age with the condition, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism

Treating Polycystic Ovary Syndrome Early May Help Prevent Later Drop in Fertility
April 4, 2017 | In adolescent girls with polycystic ovary syndrome (PCOS), bringing the amount of abdominal visceral fat and liver fat down to normal restores ovulation, normalizes the symptoms…

New Natural Estrogen-Progesterone Capsule Reduces Postmenopausal Hot Flashes
April 3, 2017 | A natural, or bioidentical, combined estradiol-progesterone capsule (TX-001HR) significantly decreases the frequency and severity of moderate to severe hot flashes…

Alcohol Abuse Even Before Pregnancy May Harm Offspring
April 2, 2017 | Mothers who binge drink before they become pregnant may be more likely to have children with high blood sugar and other changes in glucose function…

Many Transgender Individuals Consider Their Fertility Important, Survey Shows
April 2, 2017 | Nearly one-fourth of transgender individuals in Toronto, Canada, regard their own fertility as important, but most lack knowledge regarding and access to reproductive options…

Decision-Tree Tool Can Help Screen Women with Gestational Diabetes for Sleep Apnea
April 1, 2017 | Healthcare providers can use a decision-tree tool to screen women who have gestational diabetes (GDM) for obstructive sleep apnea (OSA), new research from Thailand reports…

Endocrine Society Experts Issue Clinical Practice Guideline on Hypothalamic Amenorrhea
March 22, 2017 | Female athletes and women who have eating disorders are prone to developing a condition called hypothalamic amenorrhea that causes them to stop menstruating. The Endocrine Society today issued…

Tri-Point: The Genetics and Epigenetics of Puberty
January 2017 | In 2005, the editors of Science, celebrating the journal’s 125th anniversary, posed 125 unanswered questions that it predicted would fuel active research…

Survey: Endocrinologists Want Training in Transgender Care
January 10, 2017 | Four out of five physicians who specialize in treating hormone health conditions have never received formal training on care for transgender individuals, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism

Explore highlights of current education across the Endocrine Society.


Endocrine Treatment of Gender-dysphoric/Gender-incongruent Persons
Ed. Activity | 1.0 AMA PRA Category 1 Credit™ and ABIM or ABP MOC Part 2 points
Wylie C. Hembree, MD
Throughout recorded history (in absence of an endocrine disorder) some men and women have experienced confusion and anguish resulting from rigid, forced conformity to sexual dimorphism…

Gender-Affirming Endocrine Care of Transgender and Gender Non-Binary People
ENDO Session | No credit available
Guy G. T'Sjoen, MD, PhD
Are you prepared to deliver essential endocrine care to this under-served and often misunderstood patient population?

Transitions of Care: Turner Syndrome
Practice Resource | No credit available
Resources for you and your patients to facilitate the challenging transition from pediatric to adult endocrine practice.

Explore highlights of current publications across the Endocrine Society journals. Visit academic.oup.com/endocrinesociety for more.


Systematic Characterization of Autophagy in Gestational Diabetes Mellitus
Endocrinology | August 1, 2017
Lulu Ji, Zhiguo Chen, Yating Xu, Guoping Xiong, Rui Liu, Chao Wu, Hanyang Hu, and Lin Wang
Gestational diabetes mellitus (GDM) is a metabolic disease characterized by impaired glucose intolerance beginning, or first diagnosed, during pregnancy. According to the population studies, GDM can affect 3% to 30% of pregnant women. In addition, women with a pregnancy complicated…

The Transcriptome of Estrogen-Independent Mammary Growth in Female Mice Reveals That Not All Mammary Glands Are Created Equally
Endocrinology | July 27, 2017
Grace E Berryhill, Danielle G Lemay, Josephine F Trott, Lucila Aimo, Adam L Lock, and Russell C Hovey
RNA sequencing revealed that allometric mammary growth induced by dietary conjugated linoleic acid occurs through a unique estrogen-independent and epidermal growth factor receptor–dependent mechanism.

A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications
Endocrine Reviews | June 29, 2017
Anna L Goldman, Shalender Bhasin, Frederick C W Wu, Meenakshi Krishna, Alvin M Matsumoto, and Ravi Jasuja
In the circulation, testosterone and other sex hormones are bound to binding proteins, which play an important role in regulating their transport, distribution, metabolism, and biological activity. According to the free hormone hypothesis, which has been debated extensively…

In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice
Endocrinology | June 21, 2017
Yoshinori Seki, Masako Suzuki, Xingyi Guo, Alan Scott Glenn, Patricia M. Vuguin, Ariana Fiallo, Quan Du, Yi-An Ko, Yiting Yu, Katalin Susztak, Deyou Zheng, John M. Greally, Ellen B. Katz, and Maureen J. Charron
Maternal nutrition is important in determining susceptibility to metabolic diseases. Maternal obesity and/or consumption of a high-fat (HF) diet during pregnancy and lactation…

Response to Antenatal Cholecalciferol Supplementation Is Associated With Common Vitamin D–Related Genetic Variants
JCEM | May 29, 2017
Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper, Stefania D’Angelo, Elizabeth M Curtis, Sarah R Crozier, Sheila J Barton, Sian M Robinson, Keith M Godfrey, Nikki J Graham, John W Holloway, Nicholas J Bishop, Stephen Kennedy, Aris T Papageorghiou, Inez Schoenmakers, Robert Fraser, Saurabh V Gandhi, Ann Prentice, Hazel M Inskip, M Kassim Javaid, and the Maternal Vitamin D Osteoporosis Study Trial Group
Antenatal vitamin D supplementation is now recommended for all pregnant women in many national guidelines as severe maternal vitamin D deficiency can result in symptomatic neonatal hypocalcemia. Furthermore, associations between maternal vitamin D status and obstetric complications…

Effect of Maternal Obesity on Placental Lipid Metabolism
Endocrinology | May 23, 2017
Virtu Calabuig-Navarro, Maricela Haghiac, Judi Minium, Patricia Glazebrook, Geraldine Cheyana Ranasinghe, Charles Hoppel, Sylvie Hauguel de-Mouzon, Patrick Catalano, and Perrie O’Tierney-Ginn
Sixty percent of women who become pregnant in the United States are overweight or obese [body mass index (BMI) >25 kg/m2]. Offspring of obese women have a greater risk of developing obesity and cardiovascular disease in later life…

Placental Exosomes as Early Biomarker of Preeclampsia: Potential Role of Exosomal MicroRNAs Across Gestation
JCEM | May 22, 2017 Carlos Salomon, Dominic Guanzon, Katherin Scholz-Romero, Sherri Longo, Paula Correa, Sebastian E. Illanes, and Gregory E. Rice
Each year, 10 million women worldwide develop preeclampsia (PE) and approximately 76,000 die of PE and related hypertensive disorders. The number of babies who die of these disorders is thought to be in the order of 500,000 per annum…

Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women
JES | April 25, 2017
Jose O. Aleman, Neil M. Iyengar, Jeanne M. Walker, Ginger L. Milne, Joel Correa Da Rosa, Yupu Liang, Dilip D. Giri, Xi Kathy Zhou, Michael N. Pollak, Clifford A. Hudis, Jan L. Breslow, Peter R. Holt, and Andrew J. Dannenberg
Obesity is associated with subclinical white adipose tissue inflammation, as defined by the presence of crown-like structures (CLSs) consisting of dead or dying adipocytes encircled by macrophages…

IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice
Endocrinology | April 12, 2017
Sarah C. Baumgarten, Marah Armouti, CheMyong Ko, and Carlos Stocco
Infertility is a common medical problem affecting >10% of reproductive-aged women, of whom ~40% have ovulatory dysfunction. Ovulation results from the lengthy folliculogenesis process that …

Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients
JCEM | April 3, 2017
Daniel I. Spratt, India I. Stewart, Clara Savage, Wendy Craig, Norman P. Spack, Donald Walt Chandler, Lindsey V. Spratt, Toni Eimicke, and Jerrold S. Olshan
Testosterone (T) therapy is commonly administered to hypogonadal men and female-to-male (FTM) transgender patients. Since its introduction in the 1930s, parenteral T has typically been administered intramuscularly…

Tissue-Specific Ablation of the LIF Receptor in the Murine Uterine Epithelium Results in Implantation Failure
Endocrinology | March 22, 2017
JrGang Cheng, Gracy Rosario, Tatiana V. Cohen, Jianbo Hu, and Colin L. Stewart
The cytokine leukemia inhibitory factor (LIF) is essential for rendering the uterus receptive for blastocyst implantation. In mice, LIF receptor expression (LIFR) is largely restricted…

For a complete list of Endocrine Society guidelines, visit endocrine.org/guidelines.


Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons
JCEM | September 13, 2017
Wylie C Hembree, Peggy T Cohen-Kettenis, Louis Gooren, Sabine E Hannema, Walter J Meyer, M Hassan Murad, Stephen M Rosenthal, Joshua D Safer, Vin Tangpricha, and Guy G T’Sjoen
Gender affirmation is multidisciplinary treatment in which endocrinologists play an important role. Gender-dysphoric/gender-incongruent persons seek and/or are referred to endocrinologists…

Hypothalamic Amenorrhea
JCEM | March 22, 2017
Catherine M. Gordon, Kathryn E. Ackerman, Sarah L. Berga, Jay R. Kaplan, George Mastorakos, Madhusmita Misra, M. Hassan Murad, Nanette F. Santoro, and Michelle P. Warren
FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. Investigations should include assessment of systemic and endocrinologic etiologies…

Treatment of Symptoms of the Menopause
JCEM | October 7, 2015
Cynthia A. Stuenkel, Susan R. Davis, Anne Gompel, Mary Ann Lumsden, M. Hassan Murad, JoAnn V. Pinkerton, and Richard J. Santen
Menopausal hormone therapy (MHT) is the most effective treatment for vasomotor symptoms and other symptoms of the climacteric. Benefits may exceed risks for the majority…

Androgen Therapy in Women: A Reappraisal
JCEM | October 3, 2014
Margaret E. Wierman, Wiebke Arlt, Rosemary Basson, Susan R. Davis, Karen K. Miller, Mohammad H. Murad, William Rosner, and Nanette Santoro
We continue to recommend against making a diagnosis of androgen deficiency syndrome in healthy women because there is a lack of a well-defined syndrome, and…

Diagnosis and Treatment of Polycystic Ovary Syndrome
JCEM | November 20, 2013
Richard S. Legro, Silva A. Arslanian, David A. Ehrmann, Kathleen M. Hoeger, M. Hassan Murad, Renato Pasquali, and Corrine K. Welt
We suggest using the Rotterdam criteria for diagnosing PCOS (presence of two of the following criteria: androgen excess, ovulatory dysfunction, or polycystic ovaries). Establishing a…

Evaluation and Treatment of Hirsutism in Premenopausal Women
JCEM | January 14, 2009
Kathryn A. Martin, R. Jeffrey Chang, David A. Ehrmann, Lourdes Ibanez, Rogerio A. Lobo, Robert L. Rosenfield, Jerry Shapiro, Victor M. Montori, and Brian A. Swiglo
We suggest testing for elevated androgen levels in women with moderate or severe hirsutism or hirsutism of any degree when it is sudden in onset, rapidly progressive…

ENDO 2018
Dates: March 17–20, 2018
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
ENDO is the world’s largest event for presenting and obtaining the latest in endocrine science and medicine with an extensive program covering a broad array of topics, various networking opportunities, poster sessions, updates on new products and technologies at the ENDOExpo, and more.

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