Pediatric endocrinologyDedicated to the Research and Treatment of Childhood Endocrine Disorders

Hear the latest news, learn about exciting research, and apply guidelines to stay at the leading edge of understanding and treating endocrine disorders, and bridging pediatric and adult care.

Adolescent Obesity Linked to Early Mortality from Cardiovascular Diseases
June 28, 2017 | While there is solid evidence that adolescent overweight and obesity are associated with coronary heart disease (CHD) and stroke, less is known about the association between…

Childhood Obesity Quadruples Risk of Developing Type 2 Diabetes
June 2017 | Obese children have a fourfold greater risk of developing type 2 diabetes compared to normal-weight counterparts, according to a study published in the Journal of the Endocrine Society

Children at High Risk of Diabetes Should be Screened by HbA1C and Oral Glucose Tolerance Tests
April 4, 2017 | Doctors should add an oral glucose tolerance test (OGTT) to their hemoglobin A1C (HbA1C) when they screen high-risk children for prediabetes and diabetes, new research…

Urine Metabolites May Help Predict Which Obese Teens Will Develop Diabetes
April 4, 2017 | Researchers have discovered a unique metabolic “signature” in the urine of diabetic, obese black teenagers that they say may become a way to predict the development of type 2 diabetes…

Vitamin D Deficiency May Indicate Cardiovascular Disease in Overweight and Obese Children
April 4, 2017 | In overweight and obese children and adolescents, vitamin D deficiency is associated with early markers of cardiovascular disease, a new study reports. The research…

In the US Military, White Kids and Officers' Kids More Likely to Use Diabetes Control Technology
April 3, 2017 | Even with equal access to healthcare in the United States military, significant disparities in caring for children with type 1 diabetes still exist…

Brain Signals After a Meal Respond to Food Pictures More in Obese Than Lean Kids
April 3, 2017 | Brain signals that should help tell us we are full after eating appear to be dulled in obese children, according to preliminary results of a new study presented Monday at ENDO 2017…

Artificial Pancreas Improves Blood Sugar Control in Young Kids
April 3, 2017 | An artificial pancreas, which delivers insulin in an automated way to individuals with type 1 diabetes, appears to be safe and effective for use in children ages 5 to 8…

Alcohol Abuse Even Before Pregnancy May Harm Offspring
April 2, 2017 | Mothers who binge drink before they become pregnant may be more likely to have children with high blood sugar and other changes in glucose function…

Easing the Burden of Childhood Obesity
March 2017 | According to the Endocrine Society’s Facts and Figures report on Obesity, 16.9% of U.S. children age 2 to 19 years are obese, having a body mass index (BMI) at or above the 95th percentile for age and sex…

Explore highlights of current education across the Endocrine Society.

Hypophosphatasia: New Options in the Management of Alkaline Phosphatase Deficiency
ENDO Satellite Symposium | 2.0 AMA PRA Category 1 Credits™ and ABIM MOC Part 2 points
Chair: Jill H. Simmons, MD
Faculty: Nancy S. Dunbar, MD, MPH; Peter J. Tebben, MD; and Michael P. Whyte, MD
What does low alkaline phosphatase mean in practice? Recognize subtle signs of HPP in pediatric and adult patients and learn about the most recent treatment approvals.

Transitions of Care
Practice Resource | No credit available
Resources for you and your patients to facilitate the challenging transition from pediatric to adult endocrine practice. Topics include growth hormone deficiency, Turner syndrome, and type 1 diabetes.

Explore highlights of current publications across the Endocrine Society journals. Visit for more.

Adolescent Body Mass Index and Cardiovascular Disease-Specific Mortality by Midlife
JCEM | June 9, 2017
Gilad Twig, Dana Ben-Ami Shor, Ariel Furer, Hagai Levine, Estela Derazne, Nehama Goldberger, Ziona Haklai, Moran Levy, Arnon Afek, Adi Leiba, and Jeremy D. Kark
As opposted to coronary heart disease (CHD) mortality, cardiovascular mortality attributed to non-CHD causes has increased…

The Ethics of Fertility Preservation for Pediatric Patients With Differences (Disorders) of Sex Development
JES | June 1, 2017
Lisa Campo-Engelstein, Diane Chen, Arlene B. Baratz, Emilie K. Johnson, and Courtney Finlayson
Differences (disorders) of sex development are diverse conditions with variations in chromosomal, gonadal, and/or genital development. Fertility potential in this population is variable…

Somatic USP8 Gene Mutations Are a Common Cause of Pediatric Cushing Disease
JCEM | May 12, 2017
Fabio R Faucz, Amit Tirosh, Christina Tatsi, Annabel Berthon, Laura C Hernández-Ramírez, Nikolaos Settas, Anna Angelousi, Ricardo Correa, Georgios Z Papadakis, Prashant Chittiboina, Martha Quezado, Nathan Pankratz, John Lane, Aggeliki Dimopoulos, James L Mills, Maya Lodish, and Constantine A Stratakis
As in adults, adrenocorticotropic hormone (ACTH)-producing pituitary adenomas are the most common cause of endogenous hypercortisolemia in children, especially after the age of 7 years…

Early-Onset Obesity: Unrecognized First Evidence for GNAS Mutations and Methylation Changes
JCEM | April 27, 2017
Annette Grüters-Kieslich, Monica Reyes, Amita Sharma, Cem Demirci, Terry J DeClue, Erwin Lankes, Dov Tiosano, Dirk Schnabel, and Harald Jüppner
Early-onset obesity in the first year of life characterizes patients with rare monogenic defects of the leptin–melanocortin pathway or genetically defined hypothalamic syndromes, some of which can now be treated with leptin or a novel melanocortin agonist…

Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome
JCEM | April 27, 2017
Shana E. McCormack, Dong Li, Yeon Joo Kim, Ji Young Lee, Soo-Hyun Kim, Robert Rapaport, and Michael A. Levine
Pituitary stalk interruption syndrome (PSIS, ORPHA95496) is a congenital defect of the pituitary gland that is characterized by the triad of a very thin or interrupted pituitary stalk…

Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study
JES | April 25, 2017
Ali Abbasi, Dorota Juszczyk, Cornelia H. M. van Jaarsveld, and Martin C. Gulliford
Obesity is a global health epidemic that is shifting toward children and young adults. More than one-half of adults, aged ≥18 years, were obese or overweight in 2014…

Prevalence and Significance of Thyroglobulin Antibodies in Pediatric Thyroid Cancer
JCEM | April 10, 2017
Ari J. Wassner, Margaret Della Vecchia, Petr Jarolim, Henry A. Feldman, and Stephen A. Huang
Thyroid cancer is the most common endocrine malignancy in both children and adults. Although the risk of mortality from thyroid cancer is low, lifelong surveillance is mandatory due…

Association of TSH With Cardiovascular Disease Risk in Overweight and Obese Children During Lifestyle Intervention
JCEM | March 31, 2017
Jesse M. Rijks, Jogchum Plat, Elke Dorenbos, Bas Penders, Willem-Jan M. Gerver, and Anita C. E. Vreugdenhil
Overweight and obese children has an increased risk to develop cardiovascular diseases (CVDs) in which thyroid-stimulating hormone (TSH) has been suggested as an intermediary factor…

Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes
JCEM | March 9, 2017
Sheela Sathyanarayana, Samantha Butts, Christina Wang, Emily Barrett, Ruby Nguyen, Stephen M. Schwartz, Wren Haaland, Shanna H. Swan, and the TIDES Team
Adequate sex steroid hormone concentrations are essential for normal fetal genital development in early pregnancy. Our previous study demonstrated an inverse relationship between…

Genetic Variation of Follicle-Stimulating Hormone Action is Associated with Age at Testicular Growth in Boys
JCEM | February 27, 2017
Alexander S. Busch, Casper P. Hagen, Katharina M. Main, Anita Pereira, Camila Corvalan, Kristian Almstrup, Veronica Mericq, and Anders Juul
Context: Although genetic factors play a pivotal role in male pubertal timing, genome-wide association…

For a complete list of Endocrine Society guidelines, visit

Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons
JCEM | September 13, 2017
Wylie C Hembree, Peggy T Cohen-Kettenis, Louis Gooren, Sabine E Hannema, Walter J Meyer, M Hassan Murad, Stephen M Rosenthal, Joshua D Safer, Vin Tangpricha, and Guy G T’Sjoen
Gender affirmation is multidisciplinary treatment in which endocrinologists play an important role. Gender-dysphoric/gender-incongruent persons seek and/or are referred to endocrinologists…

Pediatric Obesity—Assessment, Treatment, and Prevention
JCEM | January 31, 2017
Dennis M. Styne, Silva A. Arslanian, Ellen L. Connor, Ismaa Sadaf Farooqi, M. Hassan Murad, Janet H. Silverstein, and Jack A. Yanovski
Pediatric obesity remains an ongoing serious international health concern affecting about 17% of United States children and adolescents, threatening their adult health…

The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline
JCEM | October 6, 2016
Rebecca J. Brown, David Araujo-Vilar, Pik To Cheung, David Dunger, Abhimanyu Garg, Michelle Jack, Lucy Mungai, Elif A. Oral, Nivedita Patni, Kristina I. Rother, Julia von Schnurbein, Ekaterina Sorkina, Takara Stanley, Corinne Vigouroux, Martin Wabitsch, Rachel Williams, and Tohru Yorifuji
The lipodystrophy syndromes are a heterogeneous group of rare disorders that have in common selective deficiency of adipose tissue in the absence of nutritional deprivation or catabolic state…

Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency
JCEM | April 30, 2011
Phyllis W. Speiser, Ricardo Azziz, Laurence S. Baskin, Lucia Ghizzoni, Terry W. Hensle, Deborah P. Merke, Heino F. L. Meyer-Bahlburg, Walter L. Miller, Victor M. Montori, Sharon E. Oberfield, Martin Ritzen, and Perrin C. White
We recommend universal newborn screening for severe steroid 21-hydroxylase deficiency followed by confirmatory tests. We recommend that prenatal treatment of CAH continue to be regarded…

For additional meetings, visit the Endocrine Society’s Worldwide Endocrinology Calendar at

ENDO 2018
Dates: March 17–20, 2018
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
ENDO is the world’s largest event for presenting and obtaining the latest in endocrine science and medicine with an extensive program covering a broad array of topics, various networking opportunities, poster sessions, updates on new products and technologies at the ENDOExpo, and more.