ObesitySupporting Advances in Understanding, Preventing, and Treating Obesity

Learn about the causes and considerations when treating obesity, and hear about research, healthcare, and policy are changing the landscape. Read about why weight lost is often regained and how "Growing evidence suggests that obesity is a disorder of the energy homeostasis system, rather than simply arising from the passive accumulation of excess weight" in our latest scientific statement, Obesity Pathogensis.

Adolescent Obesity Linked to Early Mortality from Cardiovascular Diseases
June 28, 2017 | While there is solid evidence that adolescent overweight and obesity are associated with coronary heart disease (CHD) and stroke, less is known about the association between…

Endocrine Society Issues Scientific Statement on Obesity's Causes
June 26, 2017 | A new Scientific Statement issued by the Endocrine Society calls for more research aimed specifically at understanding the underlying mechanisms that make it difficult to maintain long-term weight loss…

Making the Grade: Should You Get Certified in Obesity Medicine?
June 2017 | As trends go, obesity continues its climb to epidemic levels. Likewise, over the last five years the number of physicians certified in obesity medicine has increased tenfold…

Childhood Obesity Quadruples Risk of Developing Type 2 Diabetes
June 2017 | Obese children have a fourfold greater risk of developing type 2 diabetes compared to normal-weight counterparts, according to a study published in the Journal of the Endocrine Society

Study Finds Alzheimer's Disease Likely Not Caused by Low Body Mass Index
May 9, 2017 | A new large-scale genetic study found that low body mass index (BMI) is likely not a causal risk factor for Alzheimer’s disease, as earlier research had suggested…

Participation in a Weight Management Program Reduces Job Absenteeism
April 4, 2017 | Individuals with obesity who enrolled in a structured weight loss program report fewer hours missed from work after six months in the program, according to a study…

Urine Metabolites May Help Predict Which Obese Teens Will Develop Diabetes
April 4, 2017 | Researchers have discovered a unique metabolic “signature” in the urine of diabetic, obese black teenagers that they say may become a way to predict the development of type 2 diabetes…

Disrupted Stress Hormone Signals in Bone Cells Protect from Diet-Induced Obesity
April 4, 2017 | A high-calorie diet, even without a high amount of fat, causes bone loss, and both high-calorie and high-fat diets induce excessive fat gain and insulin resistance…

Brain Signals After a Meal Respond to Food Pictures More in Obese Than Lean Kids
April 3, 2017 | Brain signals that should help tell us we are full after eating appear to be dulled in obese children, according to preliminary results of a new study presented Monday at ENDO 2017…

Patients with Higher Thyroid Hormone Levels Lose More Weight After Bariatric Surgery
April 3, 2017 | Patients who have higher levels of the thyroid hormone triiodothyronine (T3) lose more weight after bariatric surgery, new research from Portugal reports. The study…

Explore highlights of current education across the Endocrine Society.

Obesity Management Workshop 2016
Workshop Webcast | 9.75 AMA PRA Category 1 Credits™ and ABIM MOC Part 2 points
Planning Chairs: Richard Atkinson, Jr., MD; Daniel Bessesen, MD; Marc-Andre Cornier, MD; and William T. Donahoo, MD
Expert faculty focus on advanced practice challenges and highlight emerging therapies and strategies for preventing, diagnosing, and managing obesity.

Obesity Management: Optimizing Care of Your Patients
CEU Satellite Symposium | 1.0 AMA PRA Category 1 Credits™
Ken Fujioka, MD
Follow patient cases to learn tactics to assess and treat your patients with obesity, as well as useful communication approaches.

Incorporating Lifestyle Changes into Obesity Management
ENDO Session | No credit available
Daniel H. Bessesen, MD
Practical tactics to have productive conversations and counsel your patient to overcome the significant challenges in changing lifestyle.

Treatment of Obesity in Diabetes
ENDO Session | No credit available
W. Timothy Garvey, MD
“Diabetes is not an isolated entity.” Learn clinical relationships between obesity and diabetes that influence treatment strategies in the larger spectrum of cardiometabolic disease.

Mechanisms Underlying Weight Loss with Bariatric Surgery: Lessons from Animal Models
ENDO Session | No credit available
Randy J. Seeley, PhD
Hear how animal models are shedding light on how bariatric surgery affect weight loss as well as many other metabolic outcomes.

Genetic Contributions to Outcomes after Bariatric Surgery
ENDO Session | No credit available
Lee M. Kaplan, MD, PhD
Learn about genetic studies being used to understand the underlying effects of metabolic surgery and act as clinical outcome predictors.

Endocrine Facts & Figures: Obesity
Research Resource | No credit available
Advisory Panel Chair: Robert A. Vigersky, MD
Updated epidemiological data and in-depth discussion on obesity, metabolic syndrome, and associated comorbidities with current citations and expert insights.

Explore highlights of current publications across the Endocrine Society journals. Visit academic.oup.com/endocrinesociety for more.

Roux-en-Y Gastric Bypass Surgery in the Management of Familial Partial Lipodystrophy Type 1
JCEM | July 30, 2017
Audrey Melvin, Claire Adams, Catherine Flanagan, Lisa Gaff, Barbara Gratton, Fiona Gribble, Geoffrey Roberts, Robert K Semple, Stephen O’Rahilly, Francesco Rubino, Anna Stears, and David B Savage
We studied the clinical response of three patients with familial partial lipodystrophy type 1 and refractory diabetes to RYGB surgery and documented dramatic clinical improvements.

Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to the Adipose Lineage
Endocrinology | July 14, 2017
Bassem M Shoucri, Eric S Martinez, Timothy J Abreo, Victor T Hung, Zdena Moosova, Toshi Shioda, and Bruce Blumberg
Undifferentiated mesenchymal stem cells are committed to the adipose lineage by activation of RXR but not PPARγ. This is mediated, in part, by a genome-wide reduction and redistribution of H3K27me3.

Obesity Pathogenesis: An Endocrine Society Scientific Statement
Endocrine Reviews | June 26, 2017
Michael W. Schwartz, Randy J. Seeley, Lori M. Zeltser, Adam Drewnowski, Eric Ravussin, Leanne M. Redman, and Rudolph L. Leibel
Obesity is among the most common and costly chronic disorders worldwide. Estimates suggest that in the United States obesity affects one-third of adults, accounts for up to one-third of total mortality…

The Gut Metagenome Changes in Parallel to Waist Circumference, Brain Iron Deposition, and Cognitive Function
JCEM | June 7, 2017
Gerard Blasco, José Maria Moreno-Navarrete, Mireia Rivero, Vicente Pérez-Brocal, Josep Garre-Olmo, Josep Puig, Pepus Daunis-i-Estadella, Carles Biarnés, Jordi Gich, Fernando Fernández-Aranda Ángel Alberich-Bayarri, Andrés Moya, Salvador Pedraza, Wifredo Ricart, Miguel López, Manuel Portero-Otin, and José-Manuel Fernandez-Real
Recent advances in research have described the potential role of gut microbiome on broad aspects of human health, including emotional behavior and cognition through the gut-brain axis…

Adolescent Body Mass Index and Cardiovascular Disease-Specific Mortality by Midlife
JCEM | June 9, 2017
Gilad Twig, Dana Ben-Ami Shor, Ariel Furer, Hagai Levine, Estela Derazne, Nehama Goldberger, Ziona Haklai, Moran Levy, Arnon Afek, Adi Leiba, and Jeremy D. Kark
As opposted to coronary heart disease (CHD) mortality, cardiovascular mortality attributed to non-CHD causes has increased…

Effect of Maternal Obesity on Placental Lipid Metabolism
Endocrinology | May 23, 2017
Virtu Calabuig-Navarro, Maricela Haghiac, Judi Minium, Patricia Glazebrook, Geraldine Cheyana Ranasinghe, Charles Hoppel, Sylvie Hauguel de-Mouzon, Patrick Catalano, and Perrie O’Tierney-Ginn
Sixty percent of women who become pregnant in the United States are overweight or obese [body mass index (BMI) >25 kg/m2]. Offspring of obese women have a greater risk of developing obesity and cardiovascular disease in later life…

Effects of Endogenous Oxytocin Receptor Signaling in Nucleus Tractus Solitarius on Satiation-Mediated Feeding and Thermogenic Control in Male Rats
Endocrinology | May 29, 2017
Zhi Yi Ong, Diana M. Bongiorno, Mary Ann Hernando, and Harvey J. Grill Oxytocin (OT), a nonapeptide well established for its roles in lactation, anxiety, and social behaviors, is also implicated in energy balance…

Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice
Endocrinology | May 11, 2017
Gota Sakai, Ikuo Inoue, Tokuko Suzuki, Takashi Sumita, Kouichi Inukai, Shigehiro Katayama, Takuya Awata, Tetsuya Yamada, Tomoichiro Asano, Hideki Katagiri, Mitsuhiko Noda, Akira Shimada, and Hiraku Ono
Insulin lowers blood glucose levels by suppressing hepatic glucose output and enhancing peripheral glucose uptake. When the blood concentration of insulin increases, hepatic glucose output decreases via suppression of gluconeogenesis and glycogenolysis and enhancement of glycolysis…

Body Mass Index and Risk of Alzheimer Disease: a Mendelian Randomization Study of 399,536 Individuals
JCEM | May 9, 2017
Liv Tybjærg Nordestgaard, Anne Tybjærg-Hansen, Børge G. Nordestgaard, and Ruth Frikke-Schmidt
Recently, data on two million people established that low body mass index (BMI) is associated with increased risk of dementia. Whether this observational association reflects a causal effect remains to be clarified…

Early-Onset Obesity: Unrecognized First Evidence for GNAS Mutations and Methylation Changes
JCEM | April 27, 2017
Annette Grüters-Kieslich, Monica Reyes, Amita Sharma, Cem Demirci, Terry J DeClue, Erwin Lankes, Dov Tiosano, Dirk Schnabel, and Harald Jüppner
Early-onset obesity in the first year of life characterizes patients with rare monogenic defects of the leptin–melanocortin pathway or genetically defined hypothalamic syndromes, some of which can now be treated with leptin or a novel melanocortin agonist…

Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women
JES | April 25, 2017
Jose O. Aleman, Neil M. Iyengar, Jeanne M. Walker, Ginger L. Milne, Joel Correa Da Rosa, Yupu Liang, Dilip D. Giri, Xi Kathy Zhou, Michael N. Pollak, Clifford A. Hudis, Jan L. Breslow, Peter R. Holt, and Andrew J. Dannenberg
Obesity is associated with subclinical white adipose tissue inflammation, as defined by the presence of crown-like structures (CLSs) consisting of dead or dying adipocytes encircled by macrophages…

Skeletal Muscle PGC1α-1 Nucleosome Position and -260 nt DNA Methylation Determine Exercise Response and Prevent Ectopic Lipid Accumulation in Men
JCEM | April 10, 2017
Sudip Bajpeyi, Jeffrey D. Covington, Erin M. Taylor, Laura K. Stewart, Jose E. Galgani, and Tara M. Henagan
Exercise training is known to increase skeletal muscle mitochondrial content and function as well as improve insulin sensitivity, contributing to amelioration of the adverse effects of obesity and…

For a complete list of Endocrine Society guidelines, visit endocrine.org/guidelines.

Pediatric Obesity—Assessment, Treatment, and Prevention
JCEM | January 31, 2017
Dennis M. Styne, Silva A. Arslanian, Ellen L. Connor, Ismaa Sadaf Farooqi, M. Hassan Murad, Janet H. Silverstein, and Jack A. Yanovski
Pediatric obesity remains an ongoing serious international health concern affecting about 17% of United States children and adolescents, threatening their adult health…

Pharmacological Management of Obesity
JCEM | January 15, 2015
Caroline M. Apovian, Louis J. Aronne, Daniel H. Bessesen, Marie E. McDonnell, M. Hassan Murad, Uberto Pagotto, Donna H. Ryan, and Christopher D. Still
Weight loss is a pathway to health improvement for patients with obesity-associated risk factors and comorbidities. Medications approved for chronic weight management can be useful adjuncts…

Endocrine and Nutritional Management of the Post-Bariatric Surgery Patient
JCEM | April 30, 2011
David Heber, Frank L. Greenway, Lee M. Kaplan, Edward Livingston, Javier Salvador, and Christopher Still
Bariatric surgery is not a guarantee of successful weight loss and maintenance. Increasingly, patients regain weight, especially those undergoing restrictive surgeries such as laparoscopic banding…

For additional meetings, visit the Endocrine Society’s Worldwide Endocrinology Calendar at endocrine.org/calendar.

Keystone Symposium on Organ Crosstalk in Obesity and NAFLD
Dates: January 21–25, 2018
Location: Keystone, Colorado
Sponsor: Keystone Symposia on Molecular and Cellular Biology

Keystone Symposium on Bioenergetics and Metabolic Disease
Dates: January 21–25, 2018
Location: Keystone, Colorado
Sponsor: Keystone Symposia on Molecular and Cellular Biology

ENDO 2018
Dates: March 17–20, 2018
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
ENDO is the world’s largest event for presenting and obtaining the latest in endocrine science and medicine with an extensive program covering a broad array of topics, various networking opportunities, poster sessions, updates on new products and technologies at the ENDOExpo, and more.