NeuroendocrinologyDedicated to the Research and Treatment of Neuroendocrine Disorders

Discover resources and tools to keep you at the leading edge in pituitary disorders, growth, and other neuroendocrine topics.

Traumatic Brain Injuries Leave Women Prone to Mental Health Problems
April 3, 2017 | Traumatic brain injuries affect the body’s stress axis differently in female and male mice, according to research presented at the Endocrine Society’s…

Brain Signals After a Meal Respond to Food Pictures More in Obese Than Lean Kids
April 3, 2017 | Brain signals that should help tell us we are full after eating appear to be dulled in obese children, according to preliminary results of a new study presented Monday at ENDO 2017…

Magnetic Brain Stimulation Causes Weight Loss by Making Gut Bacteria Healthier
April 3, 2017 | A new study finds that a noninvasive electromagnetic brain stimulation technique helps obese people lose weight, partly by changing the composition of their intestinal bacteria&hellp;

Endocrine Society Experts Issue Clinical Practice Guideline on Hypopituitarism
October 13, 2016 | Guideline calls for hormone replacement therapy to restore hormones to healthy levels. The Endocrine Society today issued a Clinical Practice Guideline that recommends treating insufficient hormone levels in individuals with hypopituitarism by replacing hormones at levels as close to the body’s natural patterns as possible. The guideline, titled “Hormonal Replacement…

Explore highlights of current education across the Endocrine Society.

Adult Growth Hormone Deficiency
CEU Satellite Session | 2.25 AMA PRA Category 1 Credits™
Chair: Mark E. Molitch, MD
Faculty: Beverly M.K. Biller, MD and Nelly Mauras, MD
Learn about testing, diagnosis, and resassessment and devise therapy and long-term managementof GH-deficient patients.

CEU Session | No credit available
Roberto R. Salvatori, MD
Follow a discussion on causes, treatment, and what patients can expect over time in cases of hypopituitarism with an emphasis on the Society’s recent practice guidelines.

Interrogating the Stowaway: Harvey Cushing and the Beginning of Pituitary Research
Fellows Workshop Session | No credit available
Michael Bliss, PhD
Hear the unique perspectives of an acclaimed medical historian on the foundation of pituitary research.

Selecting a Target in Refractory Cushing Disease
ENDO Session | No credit available
Maria Fleseriu, MD
What’s your best option? Use the latest information on medical therapies from clinical trials to treat your patients with persistent disease.

New Concepts in Corticotroph Adenoma Pathogenesis and Experimental Treatments
ENDO Session | No credit available
Günter K. Stalla, MD
Learn about leading research on Cushing disease including the role of USP8 mutations, new aspects of glucocorticoid receptor function, and use of retinoic acid for treatment.

Endocrine Fellows Series: Pituitary Disorders Conference 2016
Fellows Workshop Webcast | 14.0 AMA PRA Category 1 Credits™
Program Directors: Anne Klibanski, MD and Janet Schlechte, MD
Engage in a comprehensive program of current topics for pediatric and adult endocrine fellows including imaging, treatment modalities, practice management strategies, and practical approaches to challenging cases.

Endocrine Facts & Figures: Hypothalamic-Pituitary
Research Resource | No credit available
Advisory Panel Chair: Robert A. Vigersky, MD
Updated epidemiological data and in-depth discussion on pituitary dysfunction, pituitary adenomas, and other sellar lesions with current citations and expert insights.

Explore highlights of current publications across the Endocrine Society journals. Visit for more.

Canonical WNT Signaling Regulates the Pituitary Organizer and Pituitary Gland Formation
Endocrinology | August 16, 2017
Allison M Osmundsen, Jessica L Keisler, M. Mark Taketo, and Shannon W Davis
Deletion of β-catenin from the mouse ventral diencephalon decreases Fgf8 expression, which is necessary for Rathke’s pouch formation, where as stimulating β-catenin results in an ectopic pituitary gland.

Pseudoacromegaly: A Differential Diagnostic Problem for Acromegaly With a Genetic Solution
JES | July 14, 2017
Per Dahlqvist, Rupert Spencer, Pedro Marques, Mary N Dang, Camilla A M Glad, Gudmundur Johannsson, and Márta Korbonits
Diagnosis of acromegaly is often delayed several years after onset of symptoms. However, once the disease is suspected, the diagnostic process is usually uncomplicated. Patients occasionally present with clinical aspects of acromegaly…

Cellular Retinoic Acid–Binding Protein 1 Modulates Stem Cell Proliferation to Affect Learning and Memory in Male Mice
Endocrinology | June 19, 2017
Yu-Lung Lin, Shawna D. Persaud, Jennifer Nhieu, and Li-Na Wei
Cellular retinoic acid–binding protein 1 (Crabp1) is a conserved cytosolic protein with a high binding affinity for retinoic acid (RA). Previous gene knockout…

The Gut Metagenome Changes in Parallel to Waist Circumference, Brain Iron Deposition and Cognitive Function
JCEM | June 7, 2017
Gerard Blasco, Jose Maria Moreno-Navarrete, Mireia Rivero, Vicente Perez-Brocal, Josep Garre-Olmo, Josep Puig, Pepus Daunis-i-Estadella, Carles Biarnes, Jordi Gich, Fernando Fernandez-Aranda, Angel Alberich-Bayarri, Andres Moya, Salvador Pedraza, Wifredo Ricart, Miguel Lopez, Manuel Portero-Otin, and Jose-Manuel Fernandez-Real
Microbiota perturbations seem to exert modulatory effects on emotional behavior, stress-and pain-modulation systems in adult animals; however, limited information is available in humans…

Effects of Endogenous Oxytocin Receptor Signaling in Nucleus Tractus Solitarius on Satiation-Mediated Feeding and Thermogenic Control in Male Rats
Endocrinology | May 29, 2017
Zhi Yi Ong, Diana M. Bongiorno, Mary Ann Hernando, and Harvey J. Grill Oxytocin (OT), a nonapeptide well established for its roles in lactation, anxiety, and social behaviors, is also implicated in energy balance…

Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome
JCEM | April 27, 2017
Shana E. McCormack, Dong Li, Yeon Joo Kim, Ji Young Lee, Soo-Hyun Kim, Robert Rapaport, and Michael A. Levine
Pituitary stalk interruption syndrome (PSIS, ORPHA95496) is a congenital defect of the pituitary gland that is characterized by the triad of a very thin or interrupted pituitary stalk…

Calcium and Bone Turnover Markers in Acromegaly: A Prospective, Controlled Study
JCEM | April 12, 2017
Tina Constantin, Vin Tangpricha, Reshma Shah, Nelson M. Oyesiku, Octavian C. Ioachimescu, James Ritchie, and Adriana G. Ioachimescu
Some acromegaly patients exhibit hypercalcemia or hypercalciuria. The etiology of hypercalcemia includes primary hyperparathyroidism or 1,25-dihydroxy-vitamin D [1,25(OH)2D] excess. Studies in patients …

Neonatal Inhibition of DNA Methylation Alters Cell Phenotype in Sexually Dimorphic Regions of the Mouse Brain
Endocrinology | April 7, 2017
Morgan Mosley, Jill Weathington, Laura R. Cortes, Emily Bruggeman, Alexandra Castillo-Ruiz, Bingzhong Xue, and Nancy G. Forger
Many of the best-studied neural sex differences relate to differences in cell number and are due to the hormonal control of developmental cell death. However, several prominent neural sex differences persist…

Neurosecretory Protein GL, a Hypothalamic Small Secretory Protein, Participates in Energy Homeostasis in Male Mice
Endocrinology | March 17, 2017
Daichi Matsuura, Kenshiro Shikano, Takaya Saito, Eiko Iwakoshi-Ukena, Megumi Furumitsu, Yuta Ochi, Manami Sato, George E. Bentley, Lance J. Kriegsfeld, and Kazuyoshi Ukena
The discovery of leptin, an anorexigenic peptide hormone secreted from adipose tissues, helped to clarify the means by which body composition…

In Vitro Head-to-Head Comparison Between Octreotide and Pasireotide in GH-Secreting Pituitary Adenomas
JCEM | March 13, 2017
Federico Gatto, Richard A. Feelders, Sanne E. Franck, Peter M. van Koetsveld, Fadime Dogan, Johan M. Kros, Sebastian J. C. M. M. Neggers, Aart-Jan van der Lely, Steven W. J. Lamberts, Diego Ferone, and Leo J. Hofland
First-generation somatostatin analogs (SSAs), such as octreotide (OCT), are the first line medical therapy for acromegaly. Pasireotide (PAS), a newly developed SSA, has shown promising results in the treatment of acromegaly…

A Thalamo-Hypothalamic Pathway That Activates Oxytocin Neurons in Social Contexts in Female Rats
Endocrinology | November 14, 2016
Melinda Cservenák, Dávid Keller, Viktor Kis, Emese A. Fazekas, Hanna Öllös, András H. Lékó, Éva R. Szabó, Éva Renner, Ted B. Usdin, Miklós Palkovits, and Árpád Dobolyi
Oxytocin, as a reproductive hormone of hypothalamic origin, is secreted from the neurohypophysis to evoke uterus…

For a complete list of Endocrine Society guidelines, visit

Hormonal Replacement in Hypopituitarism in Adults
JCEM | October 13, 2016
Maria Fleseriu (chair), Ibrahim A. Hashim, Niki Karavitaki, Shlomo Melmed, M. Hassan Murad, Roberto Salvatori, and Mary H. Samuels
Using an evidence-based approach, this guideline addresses important clinical issues regarding the evaluation and management of hypopituitarism in adults, including appropriate biochemical assessments, specific therapeutic decisions…

JCEM | October 30, 2014
Laurence Katznelson, Edward R. Laws Jr, Shlomo Melmed, Mark E. Molitch, Mohammad Hassan Murad, Andrea Utz, and John A. H. Wass
Using an evidence-based approach, this acromegaly guideline addresses important clinical issues regarding the evaluation and management of acromegaly, including the appropriate biochemical assessment, a therapeutic algorithm…

Treatment of Cushing's Syndrome
JCEM | July 29, 2015
Lynnette K. Nieman, Beverly M. K. Biller, James W. Findling, M. Hassan Murad, John Newell-Price, Martin O. Savage, and Antoine Tabarin
Treatment of Cushing's syndrome is essential to reduce mortality and associated comorbidities. Effective treatment includes the normalization of cortisol levels or action. It also includes…

Diagnosis and Treatment of Hyperprolactinemia
JCEM | July 2, 2013
Shlomo Melmed, Felipe F. Casanueva, Andrew R. Hoffman, David L. Kleinberg, Victor M. Montori, Janet A. Schlechte, and John A. H. Wass
Practice guidelines are presented for diagnosis and treatment of patients with elevated prolactin levels. These include evidence-based approaches to assessing the cause of hyperprolactinemia, treating drug-induced…

Evaluation and Treatment of Adult Growth Hormone Deficiency
JCEM | July 2, 2013
Mark E. Molitch, David R. Clemmons, Saul Malozowski, George R. Merriam, and Mary Lee Vance
Growth Hormone Deficiency (GHD) can persist from childhood or be newly acquired. Confirmation through stimulation testing is usually required unless there is a proven genetic/structural…

Pituitary Incidentaloma
JCEM | July 2, 2013
Pamela U. Freda, Albert M. Beckers, Laurence Katznelson, Mark E. Molitch, Victor M. Montori, Kalmon D. Post, and Mary Lee Vance
We recommend that patients with a pituitary incidentaloma undergo a complete history and physical examination, laboratory evaluations screening for hormone hypersecretion and for hypopituitarism, and…

The Diagnosis of Cushing's Syndrome
JCEM | January 14, 2009
Lynnette K. Nieman, Beverly M. K. Biller, James W. Findling, John Newell-Price, Martin O. Savage, Paul M. Stewart, and Victor M. Montori
After excluding exogenous glucocorticoid use, we recommend testing for Cushing's syndrome in patients with multiple and progressive features compatible with the syndrome, particularly those with…

For additional meetings, visit the Endocrine Society’s Worldwide Endocrinology Calendar at

ENDO 2018
Dates: March 17–20, 2018
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
ENDO is the world’s largest event for presenting and obtaining the latest in endocrine science and medicine with an extensive program covering a broad array of topics, various networking opportunities, poster sessions, updates on new products and technologies at the ENDOExpo, and more.

9th International Congress of Neuroendocrinology
Dates: July 15 - 18, 2018
Sponsor: International Neuroendocrine Federation(INF) & the Society for Behavioural Neuroendocrinology (SBN)
Location: Toronto, Ontario, Canada